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1. The first few presentations were on the pricing of medicines in India. The presentation from the National Pharmaceutical Pricing Authority which is responsible for medicines prices but is NOT under the Ministry of Health ; was interesting in showing the focus of affordability but the constraints of encouraging industry. 2. The tried and tested 'Essential Medicines' which are important to public health, are not high margin items and therefore, unattractive to the industry. Rigorous price control might drive pharmaceutical companies out of the essential medicines market. Most of the essential medicines had now been removed from price control though prices were monitored. There were differing opinions as to whether this creates a shortage or not. However, the data on prices clearly showed a wide variation in the same drug with prices differing sometimes by 1000%. It appeared that in this 'jungle', pharmaceutical companies wore different guises. For example, some of the major companies provided very cheap essential medicines in one section e.g. cardiovascular ; and then sold very high priced branded versions of essential medicines in another segment e.g. respiratory ; . There were examples of extreme price variation such as Rs. 25 - for ten tablets from a very big Indian pharmaceutical company and Rs. 525 - for the same drug from a multi-national company. The data presented and the vigorous discussion reinforced the fact that there was no system in pharmaceutical prices and the necessity for government intervention to regulate the market in a manner that could give reasonably priced essential medicines as well as reasonable return to the pharmaceutical company. 3. The presentations from the other countries clearly showed that when there was no price regulation Nepal, Maldives, Indonesia ; , there was extreme variation in the prices and also an incentive for other activities in medicines. For example, some of the most expensive drugs were the best sellers and were manufactured in Nepal. This is a very unusual situation in that these products would have to compete against major Indian pharmaceutical companies who could provide very good products at much more reasonable prices. A possible explanation of the high prices was the intense advertising and promotion that persuaded the doctors to prescribe the Nepali products and make them the best selling ones. Obviously, the advertising and promotion added to the cost. In Indonesia there was no price control and at the point of delivery, the pharmacists could charge whatever price they thought was appropriate. One example of regulation in an unregulated market showed what could be achieved. In Nepal, the price of intravenous fluids was regulated and in the private sector the cost was only 50% more than the public sector. However, for albendazole, a common drug used for worm treatment, there was a huge differential of 2250% between the public and private sector. The complexity, duration, and expense of the impending litigation was, for all parties, enormous; 3 ; that future discovery would be expensive but 4 ; that the plaintiffs chances for prevailing on the merits remained slim; 5 ; that even if plaintiffs were to prevail on the merits, there are significant jurisdictional obstacles to recovery; and 6 ; that Class and Defense Counsel concurred in the court's judgment. There is extensive support in the record for each proposition, particularly in the transcript of the fairness hearing. In the remainder of this discussion we address only the Objectors' more specific arguments. C. The statement of Allen Objectors Burton Carlson and Gilbert Viets, former Andersen employees, was submitted in an affidavit: AWSC was the entity in charge of establishing and enforcing accounting and professional standards, as well as quality control techniques and procedures of, educating and training personnel of, and coordinating client services on a worldwide basis for, all of its member firms, including Arthur Andersen LLP and any other affiliated entities.21 First, these facts, even if true, were insufficient to create liability for AWSC when the same relationship between Andersen U.S. and AWSC was adjudicated in In re WorldCom, Inc., 2003 WL 21488087 S.D.N.Y. June 25, for example, www differin. A.T. Dann1, K.P. Anna1, P.T. Seed1, L. Poston1, A.I. Mallet2, A.H. Shennan1 and R.M. Tribe1 and Fetal research unit, Department of Reproductive Health, Endocrinolgy and Development, King's College London, London, UK and 2School of Science, Greenwich University, Chatham, Kent, UK Assessment of serum bile acids is central to the diagnosis of many liver disorders. The methods currently available are time consuming and do not allow the simultaneous measurement of a range of bile acids and their associated conjugates. The aim of this study was to develop a high performance liquid chromatography HPLC ; electrospray ionisation mass spectrometry. It is specific in that it does not inhibit other proteases such as thrombin. Elastase, when added to the lungs of mice, causes haemorrhage and increase in permeability of epithelial cells MNEI inhibits both if given as pre-treatment. If rats are inoculated with Pseudomonas and inhaled MNEI is given daily, see decrease in treated rats of elastase, decreased lung injury and enhanced bacterial clearance of PA based on colony counts MNEI is not an antibacterial. Interferon-gamma IFNG ; in CF Although the interferons are considered to be cytokines, gamma interferon inhibits viral replication and cell proliferation and activates the immune system. IFNG also limits fibrosis via decreasing fibroblast proliferation and collagen formation. It modulates a number of cytokines - IL8 but TFN and IL6 ie downregulates the TH2 process. Previous work with IFNG: Dr Hoiby: - 1995 showed it modified immune responses in animals infected with PA CF mice INFG alters cytokine profile in BAL and reduced weight loss with PA injection Human CF chronic infection with PA causes reduction in IFNG production and IFNG may be absent during acute infections. A pilot clinical study in California has been initiated with 30 of 60 planned patients enrolled-drug given by inhalation. Anti-Inflammatory monoclonal antibodies Monoclonal a bs are expanding in number and indications as potentially specific treatments for various diseases. There are currently 10 approved products in USA eg RSV prophylaxis, cancer, Crohns disease etc ; , and 70 or so clinical trial. Although there are none specifically for CF, potential strategies include: anti IgE for allergic disease anti IL8 anti TNF and eldepryl. There are also some `multi-outlet' fine chemical products that find broader application. A few examples are listed in Table 3.7. Table 3.7: Multi-outlet fine chemical applications. Those who have school aged children present in the zations that engage volunteers. Over one-quarhousehold and among individuals who are reliter of volunteers indicated that they did not giously active. Those who contribute volunteer more because no one had asked the most hours tend to be seniors, them. About one in ten indicated that to have lower levels of housethey did not know how to get involved, hold income, higher levels pointed to the financial cost of volof education, to not have unteering, or reported dissatisfaction children present in their with a previous volunteer experience. household and to be reliVolunteering is not evenly distribgiously active. uted throughout the population. Youth aged 15 to19 tend In 2004 the most recent CSGVP Volunteering through an organization to volunteer with different survey ; , the top one-quarter of volunBill Cook Almost 12 million Canadians or 45 per cent of the types of organizations than other teers that contributed 180 hours or more Ruby Westerman & Popeye population aged 15 and older contribute almost two volunteers e.g., education and research accounted for 77 per cent of total volunteer billion hours, an amount equivalent to one million fulland social services organizations ; and engage hours. The top 10 per cent contributed 52 per time jobs, in the course of a year, according to a recent Canada in different types of volunteer activities e.g., coaching, cent of all hours. Survey of Giving, Volunteering and Participating CSGVP ; . refereeing, or officiating, and fundraising ; . Their motivaVolunteers contribute an average of 168 hours each over tions also differ from others. They are more likely to volunHelping others directly the course of a year. teer to improve their job opportunities, to explore their own Many Canadians also help others directly on their own withCanadians are most likely to volunteer with sports and strengths, and because their friends volunteer. out working through a charitable or voluntary organization. recreation, social services, education and research, and With respect to the motivations of volunteers, The CSGVP asked Canadians about the types of support religious organizations. The most common activialmost all agreed that making a contrithey provided to individuals who did not live in their ties they perform are organising, supervising or bution to their community was an own household. Eight in ten 83 per cent ; reported co-ordinating activities or events and fundraisimportant reason for their volthey had helped others directly in the previous ing, followed by serving as unpaid members of unteering. Other frequently year. The most commonly reported activities committees or boards and engaging in teachreported reasons include: the were providing help at an individual's home, ing, educating, or mentoring. opportunity to use one's skills such as cooking, cleaning, gardening, mainteThe Internet played an important role in the and experience and being nance, painting, shovelling snow or car repairs 20 per cent of volunteers that said they used personally affected by the reported by 60 per cent ; , providing healththe Internet in some way during their volunteer cause supported by the organirelated or personal care, such as emotional supactivities, while about eight per cent said that they zation with which one volunteers. port, counselling, providing advice, visiting the Harold Cook Margaret Reed used the Internet to seek out volunteer opportunities. Volunteers readily identified a variety elderly and unpaid babysitting 50 per cent ; and The highest rates of volunteering are among youth, of barriers that kept them from volunteering helping by shopping, driving someone to the store or to those with higher levels of household income and education, more and a number of these can be addressed by the organiother appointments 46 per cent and feldene, because differin waxing. When asian americans use western medicine services, they frequently also continue to use eastern medicine treatments.

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Observation of and discussion with senior medical staff Appropriate postgraduate courses e.g. Maternal Medicine Attendance at obstetric psychiatry clinic psychiatry clinic Attachment in perinatal psychiatry Personal study and frusemide.

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Sorting out the facts: christiane northrup, md - 7 10 02 updated 4 18 2005 by christiane northrup the opinions expressed in this transcript are those of the health professional and have not been reviewed by a webmd physician and keflex.

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6E-2.002 Other Types of College Licensure. 1 ; Level I Provisional License. a ; through c ; No change. d ; A Level I provisional license shall be granted for a period up to of three, six, nine, or twelve months. If granted for less than one year, the Level I provisional license may be continued to a total maximum of one year, contingent upon the college's compliance in a timely and comprehensive manner with all terms and conditions placed by the board. In unusual circumstances, if the board finds that unexpected situations have arisen which justify more than one year, the board may grant a special extension. Unusual circumstances may include such situations as a conflict between the requirements of the college's accrediting agency and the board's customary timetable. e ; through h ; No change. i ; Notwithstanding paragraphs a ; and b ; of this subsection, an established degree-granting college which demonstrates to the board that it meets the standards for both temporary licensure and Level I provisional licensure, and which pays the application fees for both, may be granted a Level I provisional license without first having a temporary license. 2 ; Level II Provisional License. a ; through c ; No change. d ; A Level II provisional license shall be granted for a period up to of three, six, nine, or twelve months. If granted for less than one year, the Level I provisional license may be continued to a total maximum of one year, contingent upon the college's compliance in a timely and comprehensive manner with all terms and conditions placed by the board. In unusual circumstances, if the board finds that unexpected situations have arisen which justify more than one year, the board may grant a special extension. e ; through i ; No change. 3 ; through 4 ; No change. 5 ; Board Form SBICU 201R, Review of License Status, effective 2000 October 1993, is hereby incorporated by reference and made a part of this rule. Copies of this form may be obtained without cost by contacting the State Board of Independent Colleges and Universities, Department of Education, Tallahassee, Florida 32399. See Rule 6E-1.0031 7 ; , FAC, for Board Forms SBICU 500 and 550.

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Ner. SR 142948A therefore likely blocks the behavioral effects of antipsychotic drugs by blocking the neurobiological consequences of antipsychotic drug-stimulated NT release. In addition, the NT receptor antagonist alone did not affect PPI, in contrast to other PPI-disrupting compounds such as DA agonists and NMDA receptor antagonists, which may also interfere with the effects of antipsychotic drugs Swerdlow and Geyer, 1998 ; . The U-shaped doseresponse curve for SR 142948A in the LI paradigm is similar to the bimodal doseresponse curves previously reported with SR 142948A and seems to characterize responses to NT receptor activation as well as antagonism Gully et al., 1997 ; . The bimodal effects of NT and SR 142948A may stem from the opposing effects of presynaptic versus postsynaptic NT receptors on DA neurotransmission. For example, at low doses, local in vivo application of NT decreases DA release and increases GABA release in a TTX-sensitive manner O'Connor et al., 1992 ; . Coadministration of the GABAA antagonist bicuculine prevented an NT-induced decrease in DA release, suggesting that this effect is mediated by NT receptors located on GABAergic neurons. At higher doses, intra-accumbens NT increases DA release in the nucleus accumbens Chapman et al., 1992; Ferraro et al., 1997 ; . There is some anatomical evidence for NT receptors located presynaptically on DA terminals, especially in the nucleus accumbens core Dilts and Kalivas, 1989 ; , indicating that the increases in DA release could be because of the effects of NT at presynaptically located NT receptor with a lower affinity for NT than the postsynaptic receptor. There is also pharmacological evidence for distinct presynaptic versus postsynaptic NT receptor subtypes within the striatum with differing affinities for SR 142948A for review, see Le et al., 1996; Rostene et al., 1997 ; . In ` addition, SR 142948A has been shown to bind with equal affinity to both the NT1 and NT2 receptors. The LI-antagonizing effect of SR 142948A, however, is most likely mediated by its action at the high-affinity NT1 NT receptor. Similarly, studies with SR 48692, an NT receptor antagonist with relative selectivity for NT1 Gully et al., 1993 ; , showed a dose-dependent disruption of LI Lambert et al., 1995 ; , suggesting that NT2 activity is less crucial for LI expression. Effects on NT2 have to be considered, however, because SR 142948A has high affinity for this receptor and NT2 mRNA is present in non-DAergic cells in the midbrain as well as in accumbal neurons Walker et al., 1998 ; . In humans, explicitly antipsychotic effects are only observed in schizophrenic patients but not in normal controls, suggesting that the neurochemical effects of antipsychotic drugs may be different in disrupted versus intact systems. Isolation-reared animals have been shown to have elevated basal DA levels, decreased serotonin metabolite 5-hydroxyindole-3-acetic acid, and increased release of DA in the nucleus accumbens in response to amphetamine administration compared with socially reared animals Hall et al., 1998 ; . The establishment of a doseresponse curve for the effects of quetiapine on PPI in both rearing groups showed that, although lower doses 2.0 mg kg ; of quetiapine specifically affected isolation-reared animals, higher doses 4.0 and 5.0 mg kg ; had PPI-enhancing effects in both groups of animals. The NT receptor antagonist partially blocked the effects of quetiapine 5.0 mg kg ; in isolation but not in socially reared animals. NT neurotransmission appears, therefore, to be preferentially involved in antipsychotic drug-induced restoration of deficits in PPI but not in the enhancement of PPI above levels seen in socially reared control animals, and perhaps by extension, the therapeutically relevant effects of antipsychotic drugs in a disrupted system. The hypothesized deficit in gating or internal screening of and hytrin and differin. Of the Cardiovascular Pathology Service in the Cleveland Clinic Reference Laboratory. He is boardcertified in anatomic and clinical pathology and holds joint appointments in Anatomic Pathology, Thoracic and Cardiovascular Surgery and Molecular Cardiology. A graduate of the Universidad Autonoma Metropolitana-Xochimilco, Mexico City, he served a residency at George Washington University Medical Center, Washington, D.C. and a fellowship with the National Heart, Lung and Blood Institute, NIH, Bethesda MD. Dr. Rodriguez can be reached at 216.444.2091 or by e-mail at rodrigr2 ccf. Prescription for healthy lighting esp. for seniors and aripiprazole. Being live other animals ceftin line with dlfferin agenda. Poppy is also regarded as an important medicinal plant. P fukuoka city bi-digital o-ring test study group & hori dental clinic, fukuoka city abstract purpose i have diagnosed the patients who complained about bruxism and articulation, and treated them by antibiotic medication by using bi-digital o-ring test originally developed by prof.

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Policy no. CORP COMM 5 Version 2 APPENDIX 5 "The aim was to: appreciate the factors that might influence managers and doctors to have differing perspectives gain a shared understanding of developments in training and education experience working together. Been shown to decrease in the presence of 1%, 2%, or 4% halothane in vitro in rat alveolar type II cells 5 ; . However, the mechanism by which halothane decreased both Na absorption and Na , K ATPase activity could not be determined 5 ; . This apparent species difference with regard to the effects of volatile anesthetics on AFC serves as an impetus for future investigation. Another important finding was that halothane administration resulted in a significantly decreased alveolar amiloride concentration approximately 0.5 mM ; compared with animals anesthetized with fentanyl and droperidol approximately 0.7 mM ; . Our in vitro experiments demonstrate that halothane does not directly decrease the amiloride concentration in 5% BSA in 0.9% NaCl. Amiloride is actively transported from the airways of sheep 20 ; , so perhaps halothane may up-regulate this process in rabbits. The alveolar amiloride concentration observed after fentanyl and droperidol anesthesia was similar to that reported by us in rabbits anesthetized with 1% isoflurane 11 ; and in rabbits anesthetized with fentanyl and droperidol 12 ; . Indeed, if the alveolar amiloride concentration was 0.5 mM in rabbits administered isoflurane, there was no discernible inhibition of AFC 11 ; . Consequently, halothane-anesthetized rabbits had alveolar amiloride concentrations associated with ineffective inhibition of amiloride-sensitive AFC pathways that nevertheless inhibited AFC to a similar extent as that observed in rabbits administered fentanyl and droperidol. One explanation for this phenomenon is that, although halothane may increase alveolar amiloride clearance, halothane may paradoxically decrease AFC by synergistically interacting with the amiloride present to inhibit amiloride-sensitive AFC pathways. However, the tacit assumption of this hypothesis is that the alveolar amiloride concentration is the primary determinant of amiloride-mediated inhibition of AFC, and the pharmacokinetics and pharmacodynamics of amiloride dissolved in 5% BSA in the alveolar space have not been extensively investigated. Overall, depending on the anesthetic administered, differing alveolar amiloride concentrations may be associated with similar inhibition of the amiloride-sensitive fraction of AFC. Our previous investigations of AFC in the rabbit reported that the amiloride-sensitive fraction of AFC two hours after instillation of BSA solution varied between 67% and 75% of total AFC 11, 12 ; . The current study reports an amiloride-sensitive fraction of approximately 50%, 90 minutes after instillation of 5% BSA solution. The only methodological difference between the present and previous 11, 12 ; studies is that the rabbits were subjected to one hour of mechanical ventilation before placement of the modified Fogarty catheter and instillation of 5% BSA solution. In our and eldepryl.
On this basis, the total amount recommended for reimbursement $1, 472.15 ; does not represent a majority of the medical fees of the disputed healthcare and therefore, the requestor did not prevail in the IRO decision. Consequently, the requestor is not owed a refund of the paid IRO fee. This Finding and Decision is hereby issued this 10th day of September 2002. Carol R. Lawrence Medical Dispute Resolution Officer Pursuant to 402.042, 413.016, 413.031, and 413.019 of the Act, the Medical Review Division hereby ORDERS the respondent to pay $1, 472.15 plus all accrued interest due at the time of payment to the requestor within 20 days of receipt of this order. This Order is applicable to dates of service 2 21 01 through 12 6 01 this dispute. This Order is hereby issued this 10th day of September 2002. Roy Lewis, Supervisor Medical Dispute Resolution Medical Review Division RL crl.
As ST and DA showed the greatest inhibitory effect, the binding parameters of [3H]DEX to the LAGS were measured in the presence of increasing concentrations 50-400 nM ; of these 17a-alkylated androgens. Table 2 summarizes the binding parameters of the [3H]DEX binding to the LAGS in the presenceor absenceof inhibitors. As shown in Scatchard plots 31 ; Fig. 3 ; of the binding data, both affinity and B , decreased with increasing concentrations of either ST or DA. When the apparent dissociation constants Kd ; were plotted against the concentration of either ST Fig. 3A, inset ; or DA Fig. 3B, inset ; , it was observed that the Kd values of [3H]DEX increased nonlinearly with increasing concentrations of both 17a-alkylated androgens, suggesting that the inhibition of [3H]DEX binding induced by both ST and DA was noncompetitive. When the data on binding in the presence of either ST or DA were plotted in the form of Lineweaver-Burk plots data not shown ; , it was found that inhibition of [3H]DEX binding by both 17Lu-alkylatedandrogens was a mixed noncompetitive type, i.e. both the affinity and B , of [3H]DEX were lowered along the entire range of concentrations tested. A replot of the slopesobtained from Lineweaver-Burk plots, as.

2. Fry J. Peptic ulcer disease: a profile. BMJ 1964; 2: 809. Rockall TA, Logan RF, Devlin HB, Northfield TC. Incidence and mortality of acute upper gastrointestinal haemorrhage in the United Kingdom. BMJ 1995; 311: 222-6. Laine L. Multipolar electrocoagulation in the treatment of active upper gastrointestinal haemorrhage: a prospective controlled trial. N Engl J Med 1987; 316: 1613-7. Panes J, Viver J, Forne M, Garcia-Olivares E, Marco C, Garau J. Controlled trial of endoscopic sclerosis in bleeding peptic ulcers. Lancet 1987; 2: 1292-4. Jensen DM. Heat probe for haemostasis of bleeding peptic ulcers: techniques and results of a randomised controlled trial. Gastrointest Endosc 1990; 36 5 Suppl ; : 42S-49S. 7. Matthewson K, Swain CP, Bland M, Kirkham JS, Bown SG, Northfield TC. Randomised comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers. Gastroenterology 1990; 98: 1239-44. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in peptic ulcer disease. JAMA 1994; 272: 65-9. Graham DY, Lew GM, Klein PD, et al. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric and duodenal ulcer: a randomized, controlled study. Ann Intern Med 1992; 116: 705-8. Hentschel E, Brandatatter G, Dragosics B, et al. Effect of ranitidine and amoxycillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. N Engl J Med 1993; 328: 308-12. Rauws EA, Tytgat GN. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990; 335: 1233-5. Marshall BJ. Helicobacter pylori. J Gastroenterol 1994; 89 8 Suppl ; : 116S-128S. 13. Reinbach DH, Cruickshank G, McColl KE. Acute perforated duodenal ulcer is not associated with Helicobacter pylori infection. Gut 1993; 34: 1344-7. Howsking SW, Yung MY, Chung SC, Li AK. Differing prevalance of Helicobacter pylori in bleeding and nonbleeding ulcers. Gastroenterology 1992; 102: A85. 15. Henriksson AE, Edman AC, Held M, Wadstrom T. Helicobacter pylori and acute bleeding peptic ulcer. Eur J Gastroenterol Hepatol 1995; 7: 769-71. Jensen DM, Jensen ME, King J, Gornbein J, Cheng S. The CURE Hemostasis Research Group. Prevalence of Helicobacter pylori and aspirin or NSAID utilisation in patients with ulcer haemorrhage: results of screening for a large multicenter US trial [abstract]. Gastroenterology 1998; 114: A161. 17. McColl KE, El-Nujumi AM, Chittajallu RS, et al. A study of the pathogenesis of Helicobacter pylori-negative chronic duodenal ulceration. Gut 1993; 34: 762. Jensen DM, You S, Pelayo E, Jensen ME. The CURE Hemostasis Group. The prevalence of Helicobacter pylori and NSAID use in patients with severe UGI hemorrahge and their potential role in recurrence of ulcer bleeding [abstract]. Gastroenterology 1992; 102: A90. 19. Lai KC, Hui WM, Lam SK. Bleeding ulcers have high falsenegative rates for antral Helicobacter pylori when tested with urease test [abstract]. Gastroenterology 1996; 110: 167A. Buckley M, Lee J, O'Morain C. The problem ulcer: bleeding, perforation, H. pylori-negativity and intractability. In: Hunt RH, Tytgat GN, editors. Helicobacter pylori: basic research to clinical cure. London: Kluwer Academic; 1996. 21. Cullen DJE, Hawkey GM, Greenwood DC, et al. Peptic ulcer bleeding in the elderly: relative roles of Helicobacter pylori and non-steroidal anti-inflammatory drugs. Gut 1997; 41: HKMJ Vol 5 No 2 June 1999 167. 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We will be highly dependent on the principal members of our senior management and key scientific and technical personnel. The loss of any of our personnel could have a material adverse effect on our ability to achieve our goals. We currently maintain employment agreements with the following senior officers: Steven M. Rauscher, President and Chief Executive Officer; Stephen Cohen, Senior Vice President and Chief Financial Officer; and Dominick Colangelo, Esq., Executive Vice President, Corporate Development and Operations. The term of each employment agreement continues until it is terminated by the officer or us. Our future success is dependent upon our ability to attract and retain additional qualified sales and marketing, clinical development, scientific and managerial personnel. The launch of the commercial sale of FACTIVE tablets during the second half of 2004 required us to significantly increase our hiring of new employees, primarily with expertise in the areas of sales and marketing. We will continue to increase these efforts in the future. Like others in our industry, we may face, and in the past we have faced from time to time, difficulties in attracting and retaining certain employees with the requisite expertise and qualifications. We believe that our historical recruiting periods and employee turnover rates are similar to those of others in our industry; however, we cannot be certain that we will not encounter greater difficulties in the future.