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Sensory integration, music therapy, art therapy, and therapeutic horseback riding 12. It is important to understand that while therapies such as sensory integration, music therapy, art therapy, and therapeutic horseback riding are not likely to be physically harmful when implemented by knowledgeable and experienced providers ; and may have some benefits such as physical activity, social interaction, or generalization of developmental skills ; , no adequate research evidence was found by the guideline panel about the efficacy of these as discrete interventions in young children with Down syndrome. However, just as for any child, incorporating sensory activities movement, music, art ; into other therapeutic techniques may be beneficial to overall development. Varied sensory activities may be useful if they support the attainment of specific goals. [D1] Conductive education 13. It is important to recognize that: The conductive education approach can be time intensive for both professionals and parents, and may take time away from other therapies that might be appropriate and effective for the child No evidence was found by the guideline panel about the efficacy of the conductive education approach in young children with Down syndrome [D1] HEALTH-RELATED INTERVENTIONS Evidence Ratings: [A] Strong [B] Moderate [C] Limited [dc] Developmental Characteristics study [D1] Literature searched but no evidence [D2] Literature not reviewed General Considerations About Health-Related Interventions The specific health-related interventions for any particular young child with Down syndrome will depend on the results of the child's health evaluation see page 85 ; . Many medical conditions occur more commonly in children with Down syndrome than in typically developing children. Some of these conditions are listed in Table 15 page 101 ; . It was considered beyond the scope of this guideline to evaluate the efficacy of interventions for most of these medical conditions. However, a few specific health-related interventions are and
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The Patents Second Amendment ; Bill, 1999 as modified by Joint Parliamentary Committee has revealed a serious dichotomy in India's stance on patenting of life forms. In its submission for the TRIPS review in WTO, the Indian government had argued that patents on life forms should be excluded. However, in its domestic legislation, the proposed amendments enable patents on processes to modify plants to render them free of disease and to increase their economic value. Economic Times, 20 Jan 2002 ; A Kolkata-based herbal drug and formulation company, Herbicure has applied for patent for one of the first herbal drugs for asthma, Asmakure. The company has applied for patent for this drug in India and abroad in countries including US, UK, Australia, etc. Asmakure drug has been developed as a result of the collaborative effort between Herbicure and Department of Pharmaceutical Technology, Jadavpur University, Kolkata. Asmakure aims at permanent relief of the patients from the agony of asthma and is a nonprescription drug. The drug is also 100 percent natural drug, free from all side effects. It is formulated in dry powder to keep the moisture content very low. The drug does not use any preservative or additive and is not prone to toxicity. Financial Express, 15 Feb 2002.
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Screening program for the discovery and development of antibacterial agents which disrupt the MEP pathway through the inhibition of DXP-R. Screening the entire AMRI natural product library yielded many hits which were prioritized by selectivity and mechanism of action studies. Samples which passed those filters were selected for fractionation and dereplication. This led to the discovery of a novel diketopiperazine structure which was the major metabolite in eight different fermentation extracts. Here we report the isolation, structure elucidation and biological activities of this novel compound. P-100M: ANTIPROTOZOAL AND PLANT GROWTH INIHIBITORY COMPOUNDS IN CAMPHORWEED HETEROTHECA SUBAXILLARIS LAM. ; BRITT. & RUSBY ; . Masanori Morimoto1, 3, Charles L. Cantrell1, Shabana I. Khan2, Babu L. Tekwani2, Stephen O. Duke1 Natural Products Utilization Research Unit, USDA ARS, University, MS, 38677, USA. 2National Center for Natural Product Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA. 3 Department of Applied Biological Chemistry, School of Agriculture, Kinki University, Nara, 6318505, Japan and
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The overall incidence of treatment-related adverse events was similar for both treatment groups: treatment-related adverse events occurred in 8 16% ; MFNS-treated patients and in 11 22% ; placebotreated patients see Table 4 ; . The most common treatment-related adverse event was epistaxis, which occurred in 6 12% ; MFNS-treated patients and 4 8% ; placebo-treated patients. One of the 6 MFNStreated patients experienced severe intermittent epistaxis on day 20 of the study; all other instances of epistaxis were of mild or moderate severity. One 6-year-old MFNS-treated patient and one 3-year-old placebo-treated patient discontinued treatment because of epistaxis that was considered to be treatment-related. No other patients withdrew from the study because of treatment-related adverse events and
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31 ; Priority Document No 32 ; Priority Date 33 ; Name of priority country 86 ; International Application No Filing Date 87 ; International Publication No 61 ; Patent of Addition to Application : NA Number : NA Filing Date 62 ; Divisional to to Application Number : NA Filing Date : NA 57 ; Abstract : ABSTRACT As shown in fig-1. The roller 1 ; is supported by bearings 7 ; in the housing 6 ; and the roller 1 ; is connected to encoder 12 ; . The housing 6 ; is fixed to the base. The roller 2 ; is supported by bearings 8 ; in the housing 9 ; . The housing 9 ; is mounted on guide rods with spring force 10 ; acting on it which pushes friction plate 3 ; against roller 1 ; . The friction plate 3 ; which is fixed to table 4 ; by bracket 5 ; . When the friction plate 3 ; moves linearly by table 4 ; movement the roller 1 ; rotates due to frictional resistance caused by spring 10 ; force .The roller 1 ; which is connected to encoder 12 ; also rotates. The encoder 12 ; in combination with electronic system converts rotary motion into linear distance traveled by table. There fore the frictional must always be greater than the force required to rotate encoder 12 ; and rollers 1&2 ; . To convert rotary motion of motor into linear motion of table 4 ; . The motor is mounted in place of encoder 12 ; . When the motor is made to rotate the rollers 1&2 ; rotate. So the friction plate 3 ; moves linearly, Due to the frictional resistance between rollers and friction plate caused by spring 10 ; force. The friction plate 3 ; which is fixed to table 4 ; by bracket 5 ; moves the table 4 ; linearly. There fore the frictional must always be greater than the force required to the table 4.
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Treatment of arteriosclerosis obliterans. Zbl Pharm 1983; 122: 763-765. Kostka-Trbka E, Grodziska L, Dembiska-Kie A, Basista M, Telesz E. Diprophyllinum prolongatum Polfa, Krakw ; w leczeniu zarostowej miadycy ttnic koczyn dolnych. Przeg Lek 1983; 40: 315-322. Dembiska-Kie A, Korbut R, muda A, Kostka-Trbka E, Simmet T, Peskar BA. Formation of lipoxygenase and cyclooxygenase metabolites of arachidonic acid by brain tissue. Biomed Biochim Acta 1984; 43: S222-S226. 83. wis J, Robak J, Dbrowski L, Duniec Z, Michalska Z, Gryglewski RJ. Antiaggregatory effects of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro. Pol J Pharmacol Pharm 1984; 36: 455-463. Szczeklik A, Gryglewski RJ, Sladek K, Kostka-Trbka E, muda A. Dihomo-gamma-linolenic acid in patients with atherosclerosis: effects on platelet aggregation, plasma lipids and lowdensity lipoprotein - induced inhibition of prostacyclin generation. Thromb Haemostas 1984; 54: 186-188.
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Endnotes 1. Zito, J.M., Safer, S.J., dosReis, S., Gardner, J.F., Magder, L., Soeken, K. et al. 2003 ; . Psychotropic practice patterns for youth: A 10-year perspective. Archives of Pediatric & Adolescent Medicine, 157 1 ; , 1725. 2. Zito, J.M., Safer, S.J., dosReis, S., Gardner, J.F., Boles, M., and Lynch, F. 2000 ; . Trends in the prescribing of psychotropic medications to preschoolers. Journal of the American Medical Association, 283 8 ; , 102530.
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NeuroSearch related parties: Related parties with a significant influence comprise the Executive Management, Board of Directors, subsidiaries and the associates NsGene A S and Sophion Bioscience A S. The Company also considers Bavarian Nordic A S and ZGene A S to related parties as some of their board members are also members of the Board of Directors. Transactions with related parties in the first half of 2006 In the first half of 2006, associated companies were invoiced for contract work and other paid work. NeuroSearch invoiced a net amount of DKK 28 thousand EUR 3.8 thousand ; to NsGene A S and DKK 86 thousand EUR 11.5 thousand ; to ZGene A S. In the first half of 2006, NeuroSearch was invoiced a net amount of DKK 217 thousand EUR 29.1 thousand ; from Sophion Bioscience A S for contract work. Transactions with related parties in 2005 Subsidiaries In 2005, subsidiaries were invoiced for contract work and other paid work. NeuroSearch invoiced a net amount of DKK 14 thousand EUR 1.9 thousand ; to NeuroScreen ApS, DKK 7, 163 thousand EUR 960.2 thousand ; to Poseidon Pharmaceuticals A S and DKK 2, 789 thousand EUR 373.9 thousand ; to NsExplorer A S. Associated companies In 2005, associated companies were invoiced for contract work and other paid work. NeuroSearch invoiced a net amount of DKK 71 thousand EUR 9.5 thousand ; to NsGene A S, DKK 85 thousand EUR 11.4 thousand ; to Sophion Bioscience A S and DKK 198 thousand EUR 26.5 thousand ; to ZGene A S. Management For information on remuneration paid to the members of the Executive Management and Board of Directors, please see "I.A.13. Remuneration and benefits." Transactions with related parties in 2004 Subsidiaries Subsidiaries were invoiced for contract work and other paid work. NeuroSearch invoiced a net amount of DKK 52 thousand EUR 7.0 thousand ; to Azign Bioscience A S, DKK 2, 347 thousand EUR 314.6 thousand ; to HeadExplorer A S now NsExplorer A S ; , DKK 802 thousand EUR 107.5 thousand ; to NeuroScreen ApS and DKK 686 thousand EUR 92.0 thousand ; to Poseidon Pharmaceuticals A S. Associated companies Associated companies were invoiced for contract work. NeuroSearch invoiced a net amount of DKK 247 thousand EUR 33.1 thousand ; to NsGene A S, DKK 344 thousand EUR 46.1 thousand ; to Sophion Bioscience A S and DKK 198 thousand EUR 26.5 thousand ; to ZGene A S. Azign Bioscience A S invoiced a net amount of DKK 3, 936 thousand EUR 527.6 thousand ; to NeuroSearch for property, plant and equipment and contract work.
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