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1st dam BEAUTIFUL ISLAND IRE ; : 4 wins at 2 to Italy and placed 12 times; dam of 1 previous foal: Dunamis IRE ; 03 c. by Bluebird USA , yearling. 2nd dam La Pointe GB ; : 5 wins in France and 64, 033 placed 3rd Prix Denisy, L., Prix Edellic, L. and Prix Right Royal, L.; dam of 3 winners: Beautiful Island IRE ; : see above. Ganzo Novales IRE ; : 4 wins to 2003 in France and in Spain and placed 5 times. Sharp Rally IRE ; : winner at 2, 2003 in France and placed twice. She also has a yearling filly by Fasliyev USA ; . 3rd dam JOLLY BAY by Mill Reef USA : winner at 3 viz. Pretty Polly S., L., placed viz. 4th Sun Chariot S., Gr.2; dam of 4 winners inc.: GAICK FOREST: 8 wins in Peru inc. Clasico Fair Mare, L., placed 2nd Clasico Concejo Distrital de Surco, Gr.3 and Clasico Reina Isabel II de Inglaterra, Gr.3; grandam of Ginger Lodge CHI ; placed 3rd P.Polla de Potrancas 1000 Guineas ; -Help, Gr.1 ; . La Pointe GB ; : see above. 4th dam JULIETTE MARNY: 3 wins at 3 and 74, 460 viz. Irish Guinness Oaks, Gr.1, Oaks S., Gr.1 and Oaks Trial S., Gr.3, placed twice inc. 3rd Yorkshire Oaks, Gr.1; Own sister to JULIO MARINER and Saviour; dam of 8 winners inc.: LAC LADOGA GB ; : 12 wins in France and 107, 320 inc. Grand Prix d'Aquitaine, L. and Prix Louis Desboudet, L., placed 5 times. JULY GIRL GB ; : 7 wins at 2 to Italy and 62, 880 inc. Premio Pietro Bessero, L.; dam of 6 winners inc.: Klaus Boy GB ; : 9 wins to 2004 in Italy and 112, 144 and placed 15 times inc. 3rd Premio Emanuele Filiberto, L. and Premio Andred, L. King Boy IRE ; : 3 wins at 3, 2004 in Italy, 3rd Premio Merano, L. JAUNTY JACK GB ; : 6 wins, 185, 748 inc. 4 wins at home, in Italy and in Norway inc. Premio Emanuele Filiberto, L., Gran Premio d'Italia, L. Duchess of Alba GB ; : winner at 3 and placed twice; dam of a winner: NICOBAR GB ; : 7 wins at home, in Italy and in U.S.A. and 248, 725 inc. Masai Mile S., Gr.2, Premio Emilio Turati, Gr.2, Frenger Systems Fortune S., L. and Vodafone Surrey S., L., 2nd San Francisco Breeders' Cup Mile H., Gr.2, Harry F Brubaker H., L., 3rd Oak Tree Breeders' Cup Mile S., Gr.2. Juliette Heights: placed at 3; dam of 3 winners inc.: UNKNOWN HEIGHTS NZ ; : 9 wins in South Africa inc. Michaelmas H., L. twice ; , placed 3rd Greyville 1900, Gr.2 and ICC Durban Michaelmas H., L. JULINSKY PRINCESS NZ ; : 3 wins in New Zealand inc. Selwyn River Stud South Island 2yo S., L. Stabled in Barn D Box 8, for example, amaryl 3.
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Source: Kenya Ministry of Health. Strategy for the Integration of HIV Voluntary Counseling and Testing Services and Family Planning Services. Nairobi, Kenya: National AIDS and STD Control Program and Division of Reproductive Health, 2004.
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The fourdrug FDCbased treatment and these substantially declined in 2001 and 2002; 5.1 US$ in both years compared to 12.4 US$ and 13.9 US$ for singledrug formulation in 2001 and 2002 respectively. Blister pack, loose drugs and the 4drug FDC for intensive phase: The total acquisition costs of antituberculosis drugs in the intensive phase treatment of a patient in the weight band 4054 kilograms were graphically plotted for the singledrug treatment based on loose tablets or blister packs and the fourdrug FDC as loose or blister pack tablets figure 3 ; . Blister pack prices of rifampicin were only available for the 300 mg strength. Therefore to allow for uniform comparison the price of the loose tablets of 300 mg rifampicin have been used in calculating the total acquisition costs for a fully blister pack based intensive phase treatment versus loose tablets. A fully blister pack based regimen with single drugs cost 10 US$ compared to 11 US$ for loose single drugs, a difference of 1 US$. The acquisition costs for treating the intensive phase with the 4drug FDC either in blister packs or as loose tablets was about half the price of single drugs in blister packs 5.5 US$ and 5.1 US$ compared to 10 US.
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National conditions from legislation and distribution to acceptance of generics differ significantly from country to country but Sandoz has uniformly strong market positions today. Besides its No. 1 position in Germany, where penetration of generic medicines is the highest in Europe, Sandoz ranks No. 2 in the US measured by annual net sales. Sandoz also ranks among the top three in most European markets, including France and Spain, where acceptance and penetration of generics are climbing rapidly. The US generics market is better developed than Europe: 52% of all prescriptions by volume are dispensed as generic drugs. Nevertheless, competition is intense as is pricing pressure for standard generic products. In a recent example, prices of generic glimepiride, for treatment of type 2 diabetes, dropped 95% within a few weeks of patent expiry on the innovator product Amaryl. The lean Sandoz sales force in the US targets key national distribution accounts, reflecting the freedom pharmacy chains have to dispense the generic version of a drug, when available.
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Form a polytomous grade within this clade. These sequences resolve the tribe Hippeastreae excluding Griffinia and Worsleya Griffineae Ravenna emend. ; and Hymenocallideae. Tribe Hippeastreae are the only clade in Amaryllidaceae s.s. other than tribe Amaryllideae that is supported by bootstrap and jackknife percentage greater than 90% Fig. 2 ; . Worsleya appears as sister to Chlidanthus Eustephieae ; , and Griffinia is unresolved Fig. 2 ; . A subclade representing subtribe Zephyranthinae is supported by low bootstrap percentage, but the remaining relationships within this clade are unresolved. The rest of the American tribes Eucharideae, Eustephieae, and Stenomesseae ; are not resolved by rbcL, but one unexpected clade with weak bootstrap support 55 ; encompasses all.
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Dependent kinases Cdks ; and proliferating cell nuclear antigen PCNA ; . Changes in p21 conformation could adversely affect regulation of cellular proliferation and increase the susceptibility to cancer. This study was conducted to investigate p21waf1 cip1 gene alterations and a possible association with immunohistochemical expression of p21 in human oral squamous cell carcinomas OSCC ; . Besides, p21waf1 cip1 genetic alterations and p21 imunoexpression were associated with clinicopathological parameters of oral cancer patients. Matched normal and cancer tissues from 31 patients with oral carcinomas and 50 samples of saliva from healthy individuals were screened for p21waf1 cip1 alterations by PCR polymerase chain reaction ; and SSCP single strand conformation polymorphism ; . The PCR-SSCP technique suggested the presence of two polymorphisms in exon 2 and one in exon 3. Sequence analysis confirmed the presence of the AGC Ser ; , AGA Arg ; polymorphism in codon 31 of exon 2. This substitution was more frequent in cancer patients 32.3% ; than in healthy individuals 12% ; , which was considered statistically significant. No significant association was observed between p21waf1 cip1 variant at codon 31 and imunohistochemical expression of p21. There was no significant association between p21 expression, the presence of codon 31 polymorphism and clinicopathological parameters of OSCC. Our results suggest that the polymorphism involving codon 31 of p21waf1 cip1 gene may be directly involved in development and or progression of oral squamous cell carcinomas.
1. Outline the relationship between the anterior chamber angle anatomy and acute angle glaucoma or uveitis; orbit proximity to sinuses and orbital cellulitis. 2. Outline the immune mechanisms of systemic conditions associated with eye redness and determine the rationale of pharmacotherapy of the conditions. 3. List common infectious agents causing eye redness such as blepharitis, keratitis, conjunctivitis, posterior uveitis, orbital cellulitis, for example, amayl glucophage.
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Fungicides, herbicides. Priority Date Claimed: 14 August, 2003 Germany Dr. Suwelack Skin & Health Care AG, JosefSuwelack-Strasse, D-48727 Billerbeck, Germany Representative: Uexkll & Stolberg, Beselerstrasse 4, D-22607 Hamburg, Germany.
EARLY VERSUS LATE GLYCEMIC CONTROL AND MORBIDITY IN MEDICAL INTENSIVE CARE UNIT PATIENTS Sakar M. Wahby * , Heather M. Bockheim, Karen J. McAllen, Jeffrey F. Barletta Spectrum Health, 100 Michigan Street NE, MC 001, Grand Rapids, MI, 49503 sakar.wahby spectrum-health PURPOSE: The benefit of aggressive glycemic control has been documented in surgical intensive care unit ICU ; patients, but benefits in medical ICU patients remain controversial. We chose to compare the impact of early versus late glycemic control on clinical outcomes in medical ICU patients. METHODS: Consecutive patients, 18 years of age and older who were admitted to the medical ICU were retrospectively reviewed. Patients with diabetic ketoacidosis and ICU length of stay LOS ; 5 days, or a mean blood glucose level in the ICU 180 mg dl were excluded. Selected patients were stratified to early versus late glycemic control groups. Early and late glycemic control was defined as an initial 3-day mean blood glucose value less than and greater than 130 mg dl, respectively. Clinical outcomes were compared between groups. RESULTS: Twenty patients have been evaluated to date [early control, n 7; late control, n 13]. Patient demographics were similar between groups. The initial 3-day mean blood glucose in the early-control group compared to the late-control group was 114 13 mg dl and 139 11 mg dl p 0.001 ; , respectively. There was no difference in the mean blood glucose during the entire ICU stay for the early 120 17 mg dl ; versus late 123 10 mg dl ; groups p 0.682 ; . There were no differences in infection rates [14% vs. 46% p 0.329 ; ], use of prolonged antibiotics [14% vs. 23% p 1.00 ; ], need for a blood transfusion [29% vs. 31% p 1.00 ; ], ICU LOS [7 2 days vs. 10 4 days p 0.131 ; ] or hypoglycemia [0% vs. 15% p 0.521 ; ] in the early- versus latecontrol groups. CONCLUSION: Based on preliminary data, early aggressive glucose control will not improve clinical outcomes in medical ICU patients. Goals for optimal glycemic control upon medical ICU admission require further study. Learning Objectives: Describe the benefit of tight glycemic control in the intensive care unit. List complications associated with hyperglycemia in the ICU. Self Assessment Questions: True or False: Clinical trials have shown intensive insulin therapy to reduce morbidity in medical intensive care unit patients. True or False: Intensive insulin therapy has been linked to improved survival in medical ICU patients.
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Morphology and Cell Viability Examination of HepG2 cells treated with 1 mM ET for 6 and 24 h revealed clear morphologic changes Fig. 1 ; including loss of large cytoplasmic vacuoles, and cell shrinkage and rounding-up. Statistically significant increases in apoptotic necrotic cells and a marked decrease in mitotic figures were present only at the 24-h time point Table 1 ; . Many cells exhibited concurrent mitotic spindles and necrosis. In cell count assays at 24 h, the number of cells was reduced 34% relative to the time-matched controls; mitotic figures dropped from 21.6 1000 cells to 0 1000 cells and apoptotic necrotic.
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Exported back into the cytoplasmic compartment and is still competent to undergo the ligand-dependent translocation process. Multiple rounds of hormonal signaling by recycled receptors and cross-reactive ligands under certain clinical conditions, such as recurrent forms of AR-positive prostate cancer, may contribute to the etiology of the disease. In a large number of these cases there are abnormally high levels of AR, due to either AR gene amplification or possibly to AR up-regulation after prolonged periods of androgen deprivation and antiandrogen therapy 45, 46 ; . These recurrent cancer cells expressing high levels of AR may experience adequate androgenic response caused by multiple rounds of receptor recycling through intermittent exposure of the AR to cross-reactive partial agonists of nongonadal origin. The role of exportin CRM1 chaperone proteins in the nuclear-to-cytoplasmic export of a number of proteins has been well established 27, 4749 ; . This mechanism is exquisitely sensitive to inhibition by LMB. LMB sensitivity to nuclear export of PR and GR by the immunostaining method has been examined earlier. Nuclear export of PR is insensitive to LMB 50 ; , and contradictory results have been reported for GR 51, 52 ; . Our results are consistent with the conclusion that the nuclear export of AR is mediated through an LBM-insensitive exportin-independent process, the nature of which has yet to be established. We feel that the results presented in this report concerning the LMB insensitivity of the export process are especially convincing, because 1 ; our observations were made in the living cell, without any additional intervention; and 2 ; inhibition of the nuclear export of GFP.
The presence of atypical symptoms, such as pain, bleeding, fever, cough, unilateral symptoms, purulent discharge, headache, and dyspnea, indicates alternative or complicating conditions, such as sinusitis, nasal polyps, mechanical obstruction, tumors, granulomas, cerebrospinal rhinorrhea, nonallergic rhinitis, rhinitis medicamentosa, hypothyroidism, pregnancy, asthma, and medication effects 1.
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Allegra Telfast fexofenadine ; , a non-sedating antihistamine for treatment of seasonal allergic rhinitis, and Allegra-D, a combination of fexofenadine with a decongestant, continued their exceptional growth in 1999 with an increase in sales of 67% to 4 729 million from 4 436 million in 1998, primarily due to an increase in market share in the growing U.S. antihistamine market. Hoechst Pharma received a final marketing approval from the U.S. Food and Drug Administration FDA ; for a once-daily dosing for use in children age six and older for chronic idiopathic uticaria indications in February 2000. Allegra Telfast was submitted in 1999 for marketing approval in Japan, the only major market in which this drug is not currently sold. Sales of the Cardizem diltiazem ; family, a calcium channel blocker for the treatment of hypertension and angina pectoris, declined 12% in 1999 to 4 642 million from 4 733 million in 1998. Generic competition for the main product, Cardizem CD, began in mid-1999 in the United States and is expected to continue to have a material adverse effect on sales of Cardizem CD in the coming years. The Delix Tritace ramipril ; family, an ACE inhibitor for the treatment of hypertension and congestive heart failure, performed strongly in 1999. Sales of the Delix Tritace family rose 2% to 4 370 million in 1999 from 4 363 million in 1998. Strong sales growth for this drug outside the United States, especially in Europe where sales rose 27% from 1998 due primarily to clinical results demonstrating the cardio- and nephro-protective characteristics of this product, more than offset the loss of sales in the United States following the sale of the U.S. product rights in December 1998. Hoechst Pharma sold the U.S. product rights for Altace, the brand name for ramipril in the United States, in order to concentrate its sales and marketing efforts on newly launched products. Amayl glimepiride ; , the first once-daily sulfonylurea for the oral treatment of type 2 diabetes, reported a 66% increase in 1999 sales to 4 242 million from 4 146 million in 1998. The outstanding performance of Amarjl was driven by significant growth in the United States and Europe. Amaryl is now marketed in all major countries except Japan, where the product has been approved and launch is planned for in the first half of 2000. 109.
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