09 10 07 ; - new research focuses on blood pressure control part 2 ; 08 31 oral medicines : - oral medicines : - actos tops avandia in heart safety studies 09 14 07 ; - answering reader questions 08 29 07 ; - panel recommends that avandia stay on the market 08 03 07 ; - more trouble for avandia; alternative drugs reviewed 07 20 07 ; print add to hotlist.
August encourages tender late season growth, delays hardening, and results in increased winter damage to the canes. It can sometimes reduce winter hardiness as well, resulting in loss of the plant. Regardless of what fertilizer you use, I recommend regular topdressings of compost -- at least twice a year -- combined with an organic mulch to help keep the soil healthy. Use organic mulch instead of plastic or stones. For the growing season, apply the mulch in a flat layer over the root area about two to three inches deep. If you'd like to give your roses a tonic, apply one half cup of Epsom salts magnesium sulphate ; sprinkled over the soil surface around the bush once a month from spring to late summer. Enjoy your roses this summer! l, because atenolol.
Avandia, the world's top-selling oral diabetes drug, has been under increasing scrutiny since may 21 when dr.
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Hiazolidinedione hypoglycemic agents act primarily by decreasing insulin resistance and are useful in the management of type 2 diabetes mellitus 1 ; . Troglitazone Rezulin, Parke-Davis, Morris Plains, New Jersey ; is a thiazolidinedione that has been associated with severe hepatic injury and has been withdrawn from the market in the United States and in Europe 2, 3 ; . Rosiglitazone Avandia, SmithKline Beecham [now GlaxoSmithKline], Philadelphia, Pennsylvania ; is also in this class, and isolated cases of liver damage have occurred in patients during rosiglitazone treatment 4, 5 ; . Pioglitazone Actos, Takeda Pharmaceuticals North America, Lincolnshire, Illinois ; is the newest thiazolidinedione drug; only one case of liver injury attributable to this agent has previously been published 6 ; . We describe a patient who developed acute, reversible mixed hepatocellular cholestatic liver injury while being treated with pioglitazone. This case has been reported to the manufacturer and to the U.S. Food and Drug Administration.
From page 1-Antipsychotic Tune Up Patients should be monitored for anticholinergic effects drying out effects like dry mouth, blurry vision and constipation ; . Patients should be monitored for extrapyramidal symptoms tardive dyskinesia ; and for antihistamine effects drowsiness ; . Besides monitoring for the harmful effects of these medications the goals for the medication should be established and checked. If the medication fails to provide benefit in attaining these goals, stopping the medication would seem appropriate. New information about Alzheimer's and subsequent treatments is becoming available each day. Newer antipsychotic medications, when used appropriately, are proving helpful in many situations. Appropriate monitoring and continued risk benefit analysis of continuing the medication must be considered in determining continuation of the medication. Antipsychotics in the right person can drastically improve an individual's quality of life. In others, these medications can drastically harm their quality of life and avapro.
Carry the pharmacy labels from the boxes for insulins and needles syringes lancets, and copies of your prescriptions plus a letter from your doctor about your need for them!
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Avandia is the companys second-largest product with more than $3 billion in sales last year.
Generic for Florinef ; tablet: 0.1mg dexamethasone generic for Decadron ; tablet: 0.5mg, 0.75mg, 1.5mg, methylprednisolone generic for Medrol ; tablet: 4mg prednisone generic for Deltasone ; tablet: 1mg, 5mg, 10mg, Level 2 Celestone Orapred DIABETES MELLITUS Level 1 glipizide generic for Glucotrol ; tablet: 5mg, 10mg glipizide ER generic for Glucotrol XL ; extended-release tablet: 2.5mg, 5mg, 10mg glyburide generic for Diabeta, Micronase ; tablet: 1.25mg, 2.5mg, 5mg insulin Injection, vials insulin syringe lancets Lifescan One Touch glucose test strips ; metformin generic for Glucophage ; tablet: 500mg, 850mg, 1000mg metformin ER generic for Glucophage XR ; extended-release tablet: 500mg Level 2 Actos Avanddia PL ; Glipizide-Metformin HCL PL ; Glyset Prandin Precose ESTROGENS Level 1 estradiol generic for Estrace ; tablet: 0.5mg, 1mg, 2mg estr adiol transdermal PL ; generic for Climara ; weekly patch: 0.05mg 24hr, 0.1mg estropipate generic for Ogen, Ortho-Est ; tablet: 0.625mg, 1.25mg, 2.5mg Level 2 Cenestin PL ; Estraderm Estratest Estratest HS Premarin Vivelle PL ; Vivelle Dot PL ; ESTROGEN PROGESTIN COMBO Level 2 Premphase PL ; Prempro PL ; GOUT Level 1 colchicine tablet: 0.6mg probenecid tablet: 500mg NEPHROLITHIASIS Level 1 allopurinol generic for Zyloprim ; tablet: 100mg, 300mg OCPs 1, MONOPHASIC Level 1 norethindrone acetate ethinyl estradiol PL ; generic for Loestrin ; tablet: 1mg 20mcg, 1.5mg norethindrone acetate ethinyl estradiol Fe PL ; generic for Loestrin Fe ; tablet: 1mg 20mcg, 1.5mg norethindrone & ethinyl estradiol PL ; generic for Ortho-Cyclen ; tablet: 0.25-35mcg Level 2 Ovcon PL ; Seasonale PL ; OCPs 3, MONOPHASIC Level 1 norgestimate ethinyl estradiol PL ; generic for Ortho Tri-Cyclen ; tablet: 0.18mg 35mcg 0.215mg OCPs 3, TRIPHASIC Level 1 desogest-ethin est PL ; generic for Cyclessa ; tablet: 0.1-0.025 0.125-0.025 0.15-.025mg norethindrone-eth estradiol PL ; generic for Tri-Norinyl ; tablet: 0.5-35 1-35 0.5-35mg norethindrone-eth estradiol PL ; generic for Ortho-Novum 7 ; tablet: 0.5-35 0.75-35 1.35mg OCPs 4, PROGESTINS Level 1 norethindrone PL ; generic for Ortho-Micronor ; tablet: .35mg Level 2 Ovrette PL ; OCPs 5, OTHER Level 2 Estrostep FE PL ; Mircette PL ; OTHER CARDIOVASCULAR Level 1 indomethacin generic for Indocin ; capsule: 25mg, 50mg OTHER ENDOCRINE METAB. Level 2 Glucagon PROGESTINS Level 1 medroxyprogesterone generic for Provera ; tablet: 2.5mg, 5mg, 10mg Level 2 Prometrium THYROID Level 2 Armour Thyroid Synthroid Thyrolar and
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Effect of drugs on tone level and response to e.f.s. Preparations consistently contracted in response to carbachol 0-55-55 M ; Figs. 3 and 4 ; . 5-HT 0-57-57 #M ; and prostaglandin F2, 0-28-28 zM ; . Responses to carbachol were blocked by atropine 0 35-35 M ; and responses to 5-HT were blocked by cinanserin 2-7-27 zM ; . Tetrodotoxin 0 31-31 M ; which by itself had very little or no effect on resting tone Fig. 5 ; , indicating that tone in these preparations is myogenic ; had little or no effect on the standard submaximal response to carbachol 1 5 M ; Carbachol therefore appears to act directly on the muscle. However, due to tachyphylaxis with 5-HT and prostaglandin F2 considerable difficulty was experienced in obtaining standard submaximal responses, and it was difficult to determine whether or not tetrodotoxin had an effect on the responses to these agents. The concept that the tone level attained by a preparation may influence the type of response to nerve stimulation has been examined by several workers in the past; for example a ' peripheral mechanism' was considered to operate in the stomach influencing the response.
Comment by check your sugars in 6 months, james - may 23, 2007 at now that this has been published no physician can accept the personal malpractice risk of allowing their patient to take avandia and
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The fda said patients who are taking avandia - especially those known to have underlying heart disease or who are at high risk of heart attack - should talk to a doctor about the new information.
Limited use benefit prior approval required ; . For treatment of type 2 diabetic patients who are not adequately controlled by or are intolerant to metformin and sulfonylureas or for whom these products are contraindicated. 2MG Tablet 02241112 4MG Tablet 02241113 8MG Tablet 02241114 July 2007 AVANDIA AVANDIA AVANDIA GSK GSK GSK Page 210 of 263 and
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Signage should read: CAUTION-POTENTIAL CANCER REPRODUCTIVE ; HAZARD AUTHORIZED PERSONNEL ONLY Facilities or emergency personnel should be apprised of potential hazards in the laboratory before they enter the room. Please note: A designated area may be posted with a removable sign if work with extremely hazardous agents is not continuous in the laboratory. Vapors or aerosols of CC's, RT's, or A ET's produced by analytical instruments should be captured at the site of production by local exhaust ventilation or be vented through a chemical fume hood. Spill procedures must be developed and posted in the designated area. Staff should be familiar with and have available materials which will inactivate the extremely hazardous chemical. All surfaces on which CC's, RT's, or A ET's are used or stored should be covered with an impervious material, e.g. stainless steel or plastic trays, or plastic-backed paper. The designated area must always be decontaminated when work is completed. Solid waste must be disposed of in hazardous chemical waste bags labeled with the name of the chemical used. Liquid wastes must be put into screw-top containers which are compatible with the chemical; the container must be labeled with the chemical name, and laboratory using it. Overtly contaminated analytical equipment should be labeled as such and should not be used until decontamination has been effected. Any equipment requiring maintenance or repair work should be decontaminated first. The smallest amount of chemical that is required by the procedure should be used or stored; purchase orders must not be based on financial savings. Whenever possible, the required material should be ordered in amounts equal to that required in a given procedure, so that no weighing is necessary. Environmental Services procedures should be limited to those which suppress aerosol formation, such as wet mops or special vacuum cleaners supplied with a high efficiency particulate air HEPA ; filter on the exhaust. Dry sweeping or dry mopping must not be done. All vacuum services, including water aspirators, should be protected with an absorbent or liquid trap and a HEPA filter to prevent entry of any CC into the system. If a volatile CC, RT, or A ET is used, a separate vacuum pump, placed in a chemical fume hood, should be used. Emergency Procedures for Contact with CC's, RT's, or A ET's Unfortunately, accidents happen even in the most controlled situation. If there is any contact with corrosive materials, the proper procedure is: Eye contact - use the eye wash station or any source of potable water; hold the eye lids open and flush with copious amounts of water for at least 15 minutes. Contact medical or emergency personnel in extreme cases. Always report incident to supervisor. Skin contact - use the Safety shower or submerge contaminated area with cool water for 15 minutes. If blister or reddening develops, do not scrub area, wash gently; seek medical attention. Report incident to supervisor. Clothing contact - remove contaminated clothing quickly and gently wash area with copious amounts of water. Contaminated clothing not removed may cause constant contact and more damage. Inhaled - quickly remove to fresh air and seek medical attention. Ingested - Contact Poison Center or, if MSDS available, look to see proper instructions on whether or not to induce vomiting. If not known, do not induce vomiting; call for emergency medical assistance. Storage Chemicals should be stored in compatible containers. Glass containers are usually the container of choice. To be certain, use the original container in which the material was shipped. Chemicals should be stored away from incompatible chemicals. Refer to the MSDS for known incompatibles. Be sure all secondary containers are labeled with the correct chemical name, as well as the hazard category CC, RT, or A ET ; . Keep storage to a minimum by purchasing only those quantities required for one week's use. A current inventory, listing quantity on hand and storage location of each chemical should be maintained. Transport Hazardous chemicals should be transported within the work place in compatible, sturdy outer containers. The inner container must be labeled properly. Contaminated materials to be transferred from work areas to disposal areas should be placed in a closed plastic bag or other impermeable primary container. This primary container should then be placed in a sturdy outer container which has been labeled with the name of the CC and the following: CAUTION-POTENTIAL CANCER REPRODUCTIVE ; HAZARD 21, for example, metformin.
All services a-z drug list drugs & medications diseases & conditions news & articles pill identifier interactions checker drug side effects drug image search new drug approvals new drug applications fda drug alerts clinical trial results patient care notes medical encyclopedia medical dictionary medical videos - community forums for professionals drug imprint codes medical abbreviations veterinary drugs contact us news feeds advertise here recent searches oracea supprelin-la amoxicillin etodolac carafate femhrt avandia adipex naprosyn zegerid alli viagra propecia xenical botox levitra omnicef plendil propecia vision blue adalat restasis clonidine prograf hyzaar recently approved totect acam2000 somatuline depot evithrom zingo selzentry evamist calomist privigen atralin gel more and
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Boxed WARNING: CONGESTIVE HEART FAILURE Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive heart failure in some patients. After initiation of AVANDIA, and after dose increases, observe patients carefully for signs and symptoms of heart failure including excessive, rapid weight gain, dyspnea, and or edema ; . If these signs and symptoms develop, the heart failure should be managed according to current standards of care. Furthermore, discontinuation or dose reduction of AVANDIA must be considered AVANDIA is not recommended in patients with symptomatic heart failure. Initiation of AVANDIA in patients with established NYHA Class III or IV heart failure is contraindicated.
Name change workgroup open forum n klimas, c lapp, l jason ; this was a lively discussion in which the possibility of name change was addressed by a number of health professionals and cfs patients looking at the issue from many points of view and
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It's not a stretch to suggest that many Americans don't eat the kinds of foods that provide all the daily nutritional fuel our bodies need, on a consistent basis. With harried and hurried schedules, out-of-town travel, long work weeks, baseball practice, and piano lessons, eating a balanced diet to support eye health, much less the entire body, can be nearly impossible. It's also true that some nutrients, like Zeaxanthin, are very difficult to get in the quantities necessary to support eye health. That's one reason ZeaVision developed the EyePromise Restore supplement. It provides benefits beyond building your macular pigment and increasing your.
Managing pregnancy without antivirals You may be under considerable pressure to use antivirals during your pregnancy. But what if you don't wish to? The strongest risk factor for a baby being born positive is the mother's viral load. If your viral load is low and your CD4 count is high, you may not want to begin any treatment. It is your decision, and you do have the right not to take antivirals or other medications during your pregnancy. Many healthy HIVnegative babies have now been born to women on combination antiviral therapy, but because the drugs are relatively new, the effects of many anti-HIV drugs during pregnancy and on unborn children are poorly understood. There is little data on any longterm effects on babies or children, and of course there is no data on how their children may be affected, if at all. If you do choose not to use antiviral drugs, it is extremely important to keep a close eye on your health during the pregnancy. You may need to monitor for any changes to your viral load and CD4 count more often. Delivery You and your doctor should discuss the possibility of a planned Caesarean delivery -- also known as an `elective Caesarean'. Studies have now clearly shown that the risk of transmission is halved if the baby is delivered by a Caesarean section, in conjunction with antiviral therapy during pregnancy and avoiding breastfeeding. If you have a vaginal delivery, your doctor may want to limit the time you spend in labour. Studies have shown that and
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RISPERIDONE RISPERDAL ; Tablets 0.25mg, 0.5mg, 1mg, and 4mg RISPERIDONE RISPERDAL M ; Tablets 0.5mg, 1mg and 2mg 1. For the management of manifestations of schizophrenia and related psychotic disorders. Advice from a psychiatrist is suggested prior to starting therapy. 2. For use in severe dementia for the short-term symptomatic management of inappropriate behavior due to aggression and or psychosis. Risperidone 0.25mg, 0.5mg, 1mg tablets are regular benefits of Plans A and V ; . Prescriptions written by New Brunswick psychiatrists do not require special authorization. Subsequent refills ordered by other practitioners will not require special authorization. RISPERIDONE RISPERDAL CONSTA ; Prolonged release suspension for injection 25mg, 37.5mg and 50mg vials For the treatment of schizophrenia or schizoaffective disorder patients who have: A history of non-adherence, and Inadequate control or significant side-effects from two or more oral antipsychotic medications, and Inadequate control or significant side-effects from at least one typical depot antipsychotic agent. RIVASTIGMINE EXELON ; Capsules 1.5mg, 3mg, 4.5mg and 6mg Oral Liquid 2mg mL See criteria under Cholinesterase Inhibitors. ROSIGLITAZONE AVANDIA ; Tablets 2mg, 4mg and 8mg For patients with type 2 diabetes who are not adequately controlled by diet, exercise and drug therapy. Drug therapy should include a trial of sulfonylurea and metformin, alone and in combination, unless one of these agents is not tolerated or is contraindicated.
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Avandia The Group has received lawsuits and claims filed in state and federal courts in the USA on behalf of numerous patients alleging that rosiglitazone the active ingredient in Avandiz ; has caused congestive heart failure or liver damage. None of the cases purports to be a class action. Most of the cases are in their early stages. Phenylpropanolamine Following a report from the Yale Haemorrhagic Stroke Project that found a suggestion of an association between first use of phenylpropanolamine PPA ; decongestant and haemorrhagic stroke, the Group and most other manufacturers have voluntarily withdrawn consumer healthcare products in which PPA was an active ingredient. Since the PPA product withdrawal the Group has been named as a defendant in numerous personal injury and class action lawsuits filed in state and federal courts alleging personal injury or increased risk of injury from use of products containing PPA and unfair and deceptive business practices. Plaintiffs seek remedies including compensatory and punitive damages and refunds.
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In controlled trials, 0.2% of patients treated with AVANDIA had reversible elevations in ALT 3X the upper limit of normal compared to 0.2% on placebo and 0.5% on active comparators. Hyperbilirubinemia was found in 0.3% of patients treated with AVANDIA compared with 0.9% treated with placebo and 1% in patients treated with active comparators. In the clinical program including long-term, open-label experience, the rate per 100 patient years exposure of ALT increase to 3X the upper limit of normal was 0.35 for patients treated with AVANDIA, 0.59 for placebo-treated patients, and 0.78 for patients treated with active comparator agents. In pre-approval clinical trials, there were no cases of idiosyncratic drug reactions leading to hepatic failure. In postmarketing experience with AVANDIA, reports of hepatic enzyme elevations 3 or more times the upper limit of normal and hepatitis have been received see PRECAUTIONS, General, Hepatic Effects ; . OVERDOSAGE Limited data are available with regard to overdosage in humans. In clinical studies in volunteers, AVANDIA has been administered at single oral doses of up to mg and was well-tolerated. In the event of an overdose, appropriate supportive treatment should be initiated as dictated by the patient's clinical status. DOSAGE AND ADMINISTRATION The management of antidiabetic therapy should be individualized. All patients should start AVANDIA at the lowest recommended dose. Further increases in the dose of AVANDIA should be accompanied by careful monitoring for adverse events related to fluid retention. See WARNINGS, Cardiac Failure and Other Cardiac Events. ; AVANDIA may be administered either at a starting dose of 4 mg as a single daily dose or divided and administered in the morning and evening. For patients who respond inadequately following 8 to 12 weeks of treatment, as determined by reduction in FPG, the dose may be increased to 8 mg daily as monotherapy or in combination with metformin, sulfonylurea, or sulfonylurea plus metformin. Reductions in glycemic parameters by dose and regimen are described under CLINICAL STUDIES. AVANDIA may be taken with or without food. Monotherapy: The usual starting dose of AVANDIA is 4 mg administered either as a single dose once daily or in divided doses twice daily. In clinical trials, the 4 mg twice daily regimen resulted in the greatest reduction in FPG and HbA1c. Combination Therapy: When AVANDIA is added to existing therapy, the current dose s ; of the agent s ; can be continued upon initiation of AVANDIA therapy. Sulfonylurea: When used in combination with sulfonylurea, the usual starting dose of AVANDIA is 4 mg administered as either a single dose once daily or in divided doses twice daily. If patients report hypoglycemia, the dose of the sulfonylurea should be decreased. Metformin: The usual starting dose of AVANDIA in combination with metformin is 4 mg administered as either a single dose once daily or in divided doses twice daily. It is unlikely that 27.
This issue's special feature, on which these questions are based, was commissioned from independent authors.The Life-long Learning scheme is supported by an educational grant from Mayne Pharma but the company has no editorial input. The scheme is open to all pharmacists. The information in the box below should help readers to identify knowledge gaps and undertake continuing professional development. Readers are also invited to complete the questions overleaf on inflammatory bowel disease, to test their knowledge of the articles, and send their answers, together with a stamped and addressed A5 envelope, to.
EyeMed Vision Care's EyeMed's ; parent company, the Luxottica Group, recently purchased Cole National Cole ; . What does this mean for your employees? It means that EyeMed replaced Cole Vision One as the primary vision discount program in HealthyExtensionsSM as of January 1, 2006. Discounts on contact lenses and LASIK will still be offered by TruVisionTM. New Discount Details 30 percent off retail prices for prescription eyeglasses, including standard plastic lenses single vision, bifocal and trifocal choice of any available frame and lens options such as tints, UV coating, scratch coating, etc. frequencies are unlimited 30 percent off retail prices for prescription sunglasses 30 percent off accessories Your employees now have access to discounts at nearly 10, 000 nationwide locations, including independent optometrist, ophthalmologist and optician offices, as well as retailers such as LensCrafters, Target Optical, and most Sears Optical and Pearle Vision centers. Blue Cross of California and BlueCard members can take advantage of the discount programs offered by these vendors just by presenting their ID cards.
After up to nine months of marketing experience with these two newer drugs, avania has now become clear that these newer medications have been reported in patients prescribed monotherapy.
RESULTS Patient Posttraumatic Growth Longitudinal Course of Patient Posttraumatic Growth Inventory Descriptive statistics for all variables included in the model are shown in Table 1. As described, the first step of model building was to examine the longitudinal course of PTGI. Growth curve analyses determined whether there were signif445 and avapro!
Transcriptase was inactivated at 70C for 15 min, and after cooling on ice, 5 l of stop buffer from the sequencing kit was added. To map the exact transcriptional start site, sequencing reactions were performed on the pAD2P plasmid including the upstream region of adhE2. The sequencing reaction was done with a Sequenase radiolabeled terminator cycle sequencing kit Amersham Pharmacia Biotech ; . Sequencing and reverse transcription reactions were analyzed on a 12% polyacrylamide sequencing gel. SDS-polyacrylamide gel electrophoresis PAGE ; analysis of AdhE2 expression. Cell extracts prepared from batch culture experiments were diluted in the sample buffer 36 ; at a final concentration of 400 g ml and boiled for 5 min at 100C, and 15 g of protein was loaded in an SDS12% polyacrylamide gel. The gel was stained with Coomassie brilliant blue. Purification of Strep-tag IIAdhE2. Anaerobic conditions were maintained throughout the entire purification procedure. Anaerobically grown E. coli pTSE ; 300 ml of a culture at an OD600 of 1 ; were recovered by centrifugation 3, 000 g for 15 min at 4C ; and resuspended in 3 ml buffer A 100 mM Tris-HCl [pH 7.6], 5 mM dithiothreitol, 2.5% glycerol ; . The cell suspension was sonicated in an ultrasonic disintegrator Vibracell 71434; Bioblock, Illkirch, France ; , at 0C in four cycles of 30 s with 2-min intervals between each cycle. Cell debris were removed by three centrifugations at 13, 000 g for 5 min. Avidin 600 g ; was added to the resulting supernatant, and the sample was loaded onto a StrepTactin Sepharose 1-ml bed volume column IBA GmbH ; by gravity flow. The column was washed with 7 ml of buffer B 100 mM Tris-HCl [pH 8] ; and eluted with 3 ml of buffer B containing 2.5 mM desthiobiotin. The presence of Strep-tag IIAdhE2 in the resulting fractions was assayed by immunoblotting after SDS 10% PAGE using Strep-Tactin horseradish peroxidase conjugate IBA GmbH ; at a 1: 830 dilution. Prestained low-range SDS-PAGE standards Bio-Rad, Hercules, Calif. ; were used. Silver staining was achieved with the Silver Stain Plus kit Bio-Rad ; . Analysis. The concentration of substrate and fermentation products was measured by a high-pressure liquid chromatography pump model 510; Waters Associates, Milford, Mass. ; equipped with an automatic sampler AS 100; Thermoseparation Products, San Jose, California ; , a refractometer HP104A; Bischof, France ; , and a data acquisition system Hewlett-Packard Chemstation, Les Ulis, France ; . The separation was obtained with an Aminex HPX-87H Bio-Rad ; column 300 by 7.8 mm ; . Elution was done at 25C with 0.031 mM H2SO4 at a flow rate of 0.7 ml min. Protein determination was performed according to the method of Bradford because this assay is not subject to interference by thiol reagents 5 ; with bovine serum albumin as a standard. Enzyme assays. The cell extract preparations and BDH and BYDH assays were performed in the anaerobic workstation according to the method described elsewhere 42 ; . Database comparisons and sequence analysis. DNA and amino acid analyses were performed by using the PC-Gene program Intelligenetics, Inc. ; . BLAST2 from the National Center for Biotechnology Information 1 ; network service was used to search databases for related amino acid sequences. Multiple-sequence alignments and percentages of identity between two amino acid sequences were calculated with AlignX from the Vector NTI software suite InforMax, Inc., Bethesda, Md. ; . CLONE-MANAGER SES, State Line, Pa. ; was used for cloning steps and pE5 design. Nucleotide sequence accession number. The sequence data of adhE2 were submitted to GenBank 4 ; and assigned accession number AF321779.
Based on published data, drug-eluting stents are effective in treating occlusive lesions of the coronary arteries. Little information is available about the usefulness of balloonexpandable or self-expanding drug-eluting stents in occluded peripheral arteries. In one randomized, prospective trial SIROCCO I ; , 36 patients with SFA occlusions or stenoses were treated with self-expanding nitinol stents that were either sirolimus-coated or uncoated.37 After 6 months, only a slight reduction in restenosis rates was observed among patients treated with the coated stents. In the SIROCCO II trial, a subsequent randomized, doubleblind study comparing patency outcomes with a slow-release sirolimus-eluting stent to those with a bare metal stent for treatment of femoropopliteal occlusive disease in 57 patients, results were again disappointing, as restenosis rates were comparable between the 2 subject groups 18 months after treat.
