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CRYER, P.E., pp511-550 in Endocrinology and Metabolism, Eds. Felig, P., Baxter, J.D., Broadus, A.E. and Frohman, L.A., McGraw Hill Book Co., New York, 1981. 2 ; HJEMDAHL, P., Acta Physiol. Scand. Suppl., 527, pp.1-54, 1984. 3 ; PASSON, P.G. and PEULER, J.D., Anal. Biochem., 51, pp.618-631, 1973. 4 ; UDENFRIEND, S., pp.103-104 in Fluorescence Assay in Biology and Medicine, 1, Academic Press, New York and London, 1962. 5 ; AXELROD, J. and TOMCHICK, R., J. Biol. Chem., 233, pp.702-705, 1958. 6 ; JOHNSON, G.A., KUPIECKI R.M. and BAKER, C.A., Metabolism, 29 Suppl 1 ; , pp.1106-1113, 1980. 7 ; MICHAELS, R.R., HUBER, M.J. and McCANN, D.S., Science, 192, pp.1242-1244, 1976.
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II. Comparative Pharmacology Parameters. Obtained pseudoreceptor model with a predictive ability may suggest that the compounds could follow the same mechanism of action. Compounds 3 and 6 are thus worth further pharmacological evaluation and could serve as leading structures for the design of new synthetic drug candidates. REFERENCES 1. 2. 3. Van Gaal, A. Zhang, M. M. Steijaert, I. H. de Leeuw. Int. J. Obes. 19 S3 ; , S21 1995 ; . K. S. McCully. Nat. Med. 2, 386389 1996 ; . B. P. Duell and M. R. Malinow. Curr. Opin. Lipidol. 8, 28 1997 ; . W. H. Giles, J. B. Croft, K. J. Greenlund, E. S. Ford, S. J. Kittner. Am. Heart J. 139, 446 2000 ; . J. J. Badimon, V. Fuster, L. Badimon. Circulation 86 Suppl. III ; , III-86 1992 ; . T. E. Willnow. J. Mol. Med. 77, 306 1999 ; . M. M. Hussain, D. K. Strickland, A. Bakillah. Ann. Rev. Nutr. 19, 141 1999 ; . L. Badimon, J. H. Chesebro, J. J. Badimon. Circulation 86 Suppl. III ; , III-74 1992 ; . D. Steinberg, S. Parthasarathy, T. E. Carew, J. C. Kho, J. L. Witzum. New Engl. J. Med. 320, 915 1989 ; . G. J. Miller. Baillieres Best Pract. Res. Clin. Haematol. 12, 555 1999 ; . S. P. Zhao and D. Y. Xu. Thromb. Res. 100, 501 2000 ; . P. Libby. J. Int. Med. 247, 349 2000 ; . J. L. Orford, A. P. Selwyn, P. Ganz, J. J. Pompa, C. Rogers. Am. J. Cardiol. 86 Suppl. ; , 6h 2000 ; . P. Libby. Clin. Cardiol. 23 Suppl. 6 ; , VI-3 2000 ; . D. W. Schell and J. N. Myers. Prog. Card. Dis. 39, 483 1997 ; . B. G. Brown, X. Zhao, D. E. Sacco, J. J. Albers. Circulation 87, 1781 1993 ; . D. H. Blankenhorn and D. M. Kramsch. Circulation 79, 1 1989 ; . G. Cirino, C. Cicala, F. Mancuso, A. R. Baydoun, J. L. Wallace. Thromb. Res. 79, 73 1995 ; . Maas Investigators. Lancet 344, 633 1994 ; . R. H. Bradford, C. L. Shear, A. N. Chremos, C. Dujovne, M. Downton, F. A. Franklin, A. L. Gould, M. Hesnry, J. Higgins, D. P. Hurley et al. Arch. Int. Med. 151, 43 1991 ; . J. F. Brensike, R. I. Levy, S. F. Kelsey, E. R. Passamani, J. M. Richardson et al. Circulation 69, 313 1984 ; . L. Cashin-Hemphill, W. J. Mack, J. M. Pogoda, M. E. Sanmarco, S. P. Azen, D. H. Blankenhorn. Jama 264, 3013 1990 ; . J. C. Tardif. Can. J. Cardiol. 16 Suppl. D ; , 2d 2000 ; . Nippon Soda KK. JP0120657 1998 ; . Fujisawa Pharm Co, Ltd. WO9808838 1998 ; . Schering Corp. US5756470 1998 ; . Sankyo KK. JP9202775 1997 ; . Warner-Lambert, Co. WO9744314-A 1997 ; . Taisho Seiyaku KK & Et Al. JP9110781 1997 ; . Tularik, Inc. WO9910320-A 1999 ; . Hoechst Marion Roussel Deutschland Gmbh. EP0869121 1998 ; . T. Kamisako, E. C. Gabazza, T. Ishihara, Y. Adachi. J. Gastroenterol. Hepatol. 14, 405 1999 ; . J. H. Veerkamp, R. G. Maatman. Prog. Lipid Res. 34, 17 1995 ; . L. Banaszak, N. Winter, Z. Xu, D. A. Bernlohr, S. Cowan, T. A. Jones. Adv. Prot. Chem. 45, 89 1994 ; . N. Ribarik Coe and D. A. Bernlohr. Biochim. Biophys. Acta 1391, 287 1998 ; . Bristol-Myers Squibb Co. WO0059506-A 2000 ; . N. Ribarik Coe, M. A. Simpson, D. A. Bernlohr. J. Lipid Res. 40, 67 1999 ; . Mrck Gmbh. WO003913-A 2000 ; . Takeda Chem Ind Ltd. WO9958510-A 1999 ; . 2001 IUPAC, Pure and Applied Chemistry 73, 14451458.
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