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I thought i was having an allergic reaction to the quinine which contains sulfa. The fact that in malaria patients there was no correlation between body weight and quinine vd as calculated during the elimination phase renders questionable the usefulness of dosing quinine according to body weight.

Table 2. Comparison of Complications by Treatment Group.
Appealing Agency: WHO Objectives: Malaria Prevention and Control In order to prevent malaria morbidity and mortality among the population at most immediate risk as well as to prevent and control malaria epidemics as a result of the flooding due to Cyclone Eline the following objectives should be achieved: To protect pregnant women and under-five year olds from malaria through the distribution of insecticide-treated bednets. To protect displaced populations sheltering in permanent buildings e.g. classrooms ; from malaria through residual spraying To ensure health facilities including temporary treatment camps have sufficient antimalarials for treating simple and complicated malaria To strengthen community-based malaria treatment systems To distribute malaria case management guidelines for both professional and volunteer health workers To distribute malaria IEC materials within communities To provide emergency staff for malaria epidemic control support, particularly for case management Strategy ies ; The project will prevent and control malaria for the next 3 months among the 96, 000 people most severely affected by Cyclone Eline. A two-pronged approach will be employed to reduce malaria cases and deaths. The most vulnerable groups pregnant women and under-fives will receive insecticide-treated nets ITNs ; n 19, 488 ; in order to prevent malaria. ITNs are an effective means of reducing malaria cases and deaths. However, it is essential that they are used correctly and, hence, the ITNs will be complemented with appropriate health education materials describing proper ITN usage. For pregnant women, chemoprophylaxis will also occur in accordance with Ministry of Health National Guidelines. For displaced populations sheltering in permanent buildings such as school classrooms, residual spraying with pyrethroids will occur. Early and appropriate case management is essential if malaria cases are to be treated before they develop into severe malaria. Chloroquine holders in the affected communities will be provided with case management guidelines and sufficient chloroquine. Health education materials on malaria will also be distributed by the chloroquine holders. The project will ensure that there will be adequate first-line chloroquine ; , second-line sulphadoxine-pyrimethamine ; and third-line quinine ; drugs. In addition, health workers will receive case management guidelines for simple and severe malaria. It is estimated that the Ministry of Health and Child Welfare will only be able to provide 50% of the total drug needs for the severely affected population see Table. Chance, it was still significantly higher than 0.5 mean 0.56; t 6 ; 2.63; p 0.039 ; . When scores from individual subjects were tested, only two of the seven rats had outlying scores significantly above chance, and these scores were very low R5 0.60; R11 0.66 ; . However, these same two rats performed at chance levels when tested on the quinine versus denatonium discrimination scores on last day of testing: R5 0.45; R11 0.39 ; . Finally, after the group 1 rats were successfully retested on the original quinine versus KCl task, denatonium was substituted for KCl Fig. 2 B ; . this point, performance dropped to chance levels for the remainder of the experiment [last day: t 6 ; 0.412; p 0.695; null hypothesis; P correct response ; 0.5 50% ; ]. The group 2 rats, which had initially failed to discriminate quinine from denatonium, were then trained to discriminate quinine from KCl Fig. 3B ; . Some of these rats acquired the discrimination at a slower rate than others, presumably because they were more disrupted by their early experience with the apparently impossible taste discrimination task. Nevertheless, all.

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Study Setting Date of intervention Source of funding Design Study population Recruitment procedure used Number of patients Length of study Main intervention s Primary outcome measures Secondary outcome measures Definition of incident vertebral fracture Results: vertebral fracture Results: non-vertebral fracture Quality score Comments Passeri, 1995 Italy Not specified Chiese Farmaceutici SpA Two centre, randomised, double-blind, placebo-controlled Elderly women with established osteoporosis at least one vertebral fracture, and forearm Z-score of 2 ; Patients presenting at geriatric outpatient clinics at two university hospitals for evaluation of osteoporosis 49 2 years Oral ipriflavone BMD Safety Incidence of new vertebral fractures Incidence of non-traumatic peripheral fractures, or peripheral fractures due to minimum trauma 20% or greater reduction in anterior compared with posterior vertebral height, or in posterior height compared with height of adjacent vertebrae Four women in treatment group 20% of those for whom X-rays available ; suffered new vertebral fractures compared with eight in control group 40% of those for whom X-rays available ; No women in treatment group suffered non-vertebral fractures compared with one from control group 15 18 All patients received elemental calcium, 1 g daily 22 women 44.9% ; withdrew from study: 11 44.0% ; from treatment and 11 45.8% ; from control group. Five dropped out because of adverse reactions three in treatment and two in control group ; . Of rest, five withdrew due to of intercurrent illness, two because GPs changed therapy and ten for personal reasons or loss of interest Most adverse reactions were gastrointestinal symptoms. As these equally distributed between groups, authors suggested at least some may be due to calcium supplement Authors attributed high drop-out rate to age-related difficulty involved in these patients following study protocol for long period All 27 completers used at least 75% dispensed medication during first year, and 93% continued to be good compliers defined as using 75% or more of medication ; for whole 2-year period one woman in each group used 72% ; No serious adverse events; cardiac and pulmonary function, and blood pressure remained unchanged in both groups Analysis of fracture outcomes undertaken on ITT basis. When the patient could tolerate it, therapy was continued orally in the form of tablets. The patients were discharged after completing the full dose of quinine on day 8, then seen on days 14, 21, 28, and every 2 weeks in the antenatal clinic until delivery. In the clinic they were examined by the obstetrician for weight, pallor, temperature, pulse, blood pressure, fundal level, fetal heart sounds and oedema. At every visit the patient's haemoglobin was estimated and blood films for malaria were taken. The obstetrician supervised all hospital deliveries and kept close links with those who decided to deliver at home. A paediatrician examined all the infants at birth for congenital malformations and made all necessary anthropometric measurements. Infants, both hospital- and home-delivered, were followed up to 1 year of age by the same paediatrician. Definitions Chloroquine-resistance was defined as the detection of P. falciparum malaria parasites in peripheral blood after a complete course of chloroquine. Abortion was defined as expulsion of a dead fetus before 28 weeks of gestation. Premature labour was delivery after 28 weeks and before 37 weeks of gestation. Perinatal death was death of the baby from 28 weeks in utero until the age of 1 week post-delivery. Analysis Data were analysed using SPSS PC. Simple frequency distributions, percentages, means and standard deviations were calculated. Ethics The study received ethical clearance from the Faculty Research Board at the Faculty of Medicine, University of Khartoum and the Federal Ministry of Health. Written con and ribavirin. ROBERT L. MCCARTHY AND KENNETH W. SCHAFERMEYER. Introduction to Health Care Delivery: A Primer for Pharmacists, Second Edition. Gaithersburg, MD: Aspen Publishers, Inc., 2000. xvii + 599 pp., 22 figs., 32 tbls. $51.00. 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Chloroquine was the most important antimalarial drug for decades, being used for both prophylaxis and treatment of falciparum malaria.1 It is cheap, safe and adequate for outpatient use.6 Unfortunately, resistance to its action has quickly developed, and is now widespread: chloroquine can not be used anymore in Southern Asia and in many countries in Latin America.6, 16, 17 Chloroquine still plays an important role in the treatment of acute, uncomplicated P. falciparum infections in some countries where transmission is intense, notably in tropical Africa. 15 Amodiaquine belongs to the same family of choroquine, but is less efficient, more expensive and more toxic.1, 15 Qyinine is a natural compound of relatively low potency and narrow therapeutic range, 6 and was the first compound used against malaria. It was first found in a Peruvian mountain tree called chinchona, and has been used in Europe since the 17th century.1 Resistance to quinine has been reported in Southern Asia, 18 South America19 and Africa, 20 but clinical failure is common only in Southern Asia, so that quinine has become the first option for treating severe falciparum malaria, especially after choroquine became unreliable. Intravenous infusion is the usual route for quinine administration, although deep intramuscular injection can be employed as an alternative route.6 Also, in some countries, like Brazil, oral administration of quinine is recommended.21 1uinine is used as a first-line drug for malaria treatment in some temperate countries, like the United Kingdon, a practice that is less common in tropical countries.6 The + ; isomer of quinine, known as quinidine, is more efficient than quinine, but it is also more toxic, being able to cause serious cardiac side effects in patients.1 Mixtures of cinchona alkaloids, known as totaquines, have also been used against malaria; standardized totaquines contain at least 15 % of quinine.1 Mefloquine is a 4-quinolinemethanol structurally analogous to quinine, developed by the U.S. Army in order to replace chloroquine.15 It is used only for the treatment of uncomplicated malaria in richer countries where resistance to other drugs is widespread like Thailand unfortunately, it is unaffordable for general use in tropical Africa.6 Moreover, resistance to its action has been reported in some areas in Southeast Asia, mainly in the Thai borders with Burma and Cambodia. Mefloquine may be used in combination with other drugs; for example, the combination of mefloquine with artemisinin derivatives has proven to be more efficient than the former alone.6 Another used combination, known as Fansimef, involves mefloquine and the antifolates pyrimethamine and sulfadoxine. 15 Rarely, mefloquine can cause serious idiosyncratic adverse reactions, while mild dose-related adverse effects, usually gastrointestinal, are common.1, 6.

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To date, many analysts have show great interests in flow injection technique with a CL detector. Although the most widely used CL system in FIA is luminol with hydrogen peroxide as oxidant, an acidic CL system involving potassium permanganate, cerium IV ; and rhodamine compounds seems more suitable for analysis of biochemical species since such substances are often not stable in basic media. In recent years, the use of FI methodologies with CL detection in an acidic media presents a great potential to perform the analysis for kinds of species in foods, drinks, pharmaceuticals and body fluids, and the proposed methods are described and compared according to the used CL detection system in this paper. 2. Applications of Different CL Systems in FIA 2.1. Permanganate-Based CL System in FIA It is likely that Grinberg [4], in 1920, was the first to report the use of acidic potassium permanganate KMnO4 ; as a reagent for the oxidation of pyrogallol in the presence of hydrogen peroxide. The first analytical application of acidic potassium permanganate CL reaction was published in 1975 [5]. However, until 1986, this reagent was mainly focused on the determination of sulphur dioxide. The report of Townshend [6] on morphine determination blossomed the application of acidic potassium permanganate to the analysis of drugs and organic compounds. Now, acidic potassium permanganate has been successfully employed, generally with flow analysis, as a strong oxidant to generate chemiluminescence. Of the methodologies described, many have demonstrated that this chemistry is capable of detecting a wide variety of analytes with good sensitivity, using batch techniques, flow analysis, after separation by either liquid chromatogram or, more recently, capillary electrophoresis. The KMnO4-based FI-CL methods are mainly based on the direct oxidation of the analyte by KMnO4 [7-14], or based on the enhancement of CL intensity of the KMnO4-sulfite system by the analyte [15-17], using quinine, formaldehyde, glyoxal, formic acid and some surfactants as a sensitizer. Among the wide range of compounds, the most analytes in KMnO4-based CL system possess either an amine or a phenolic moiety [18]. So far, KMnO4-based CL detection is overwhelming in the determination of pharmaceutical preparations mainly antibiotics ; . The related review has focus on the analytical application and the mechanism discussion of the system published up until mid-2001 [19]. In a word, as one of a few of acidic CL systems, KMnO4-based CL holds still a wide potential applications with a deeper understanding of the mechanisms that lead to the production of light. In Table 1, a chronological survey of the analytical applications of acidic potassium permanganate CL with FI technique for the determinations of biochemical species are listed in the last 10 years. 2.2. Cerium IV ; -Based CL System in FIA Compared with acidic KMnO4-based CL system, cerium IV ; -related CL reaction is not subject to the chloride ion [40]. Moreover, KMnO4 has strong absorption to light emission and consequently the CL intensity could decrease when the concentration of KMnO4 is too high. Instead, the sensitivity for cerium IV ; -based CL system can be improved by increasing cerium IV ; concentration since the selfabsorption of light is reduced largely in the system. Therefore, the cerium IV ; -based CL reaction in an acidic media generally in sulfuric acid medium ; has also been carried out for the determination of and ropinirole. Quantities reflect limits available at a retail pharmacy. Mail order quantities are generally available at 3 times the retail pharmacy limit max. 90-day supply ; . State and plan variations apply. If your doctor prescribes more than 34 ; 20mg tablets prescription and you are diagnosed with Homozygous Familial Hypercholesterolemia, your doctor should contact Medco to initiate a review. Some drug classes may not be covered by your plan. See your Certificate of Coverage for benefit information.
American Tinnitus Association. Web site, : ata American Diabetes Association. Web site, : diabetes Anisman, H., et al. "Neuroimmune mechanisms in health and disease." Canadian Medical Association Journal 155 8 ; Oct 1998 ; : 107582. Archives of Internal Medicine, Vol. 160, No. 11, June 12, 2000, "American Thyroid Association Guidelines for Detection of Thyroid Dysfunction." Arem, Ridha, M.D. Thyroid Solution. New York: Ballantine Books, 2000. Arizona Republic. "Pollutant Likely Migrated Via Canal." 27 August 1998. Arnot, Robert, M.D.Dr. Bob Arnot's Revolutionary Weight Control Program. Boston: Little Brown & Company, 1998. Aronne, Louis J., M.D. Weigh Less, Live Longer: Dr. Lou Aronne's "Getting Healthy" Plan for Permanent Weight Control. New York: John Wiley & Sons, 1996. Atcheson, Steven G., M.D. "Concurrent Medical Disease in WorkRelated Carpal Tunnel Syndrome." Arch Intern Med, July 27, 1998 et al., 158 1998 ; : 150612. : Avww.ama-assn sci-pubs journals archive inte vol 158 no 14 ioi70670 Balch, James F., M.D., and Phyllis Balch. Prescription for Nutritional Healing: A Practical AZ Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements. Garden City Park, NY: Avery, 1996. Barnes, Broda O., M.D., and Lawrence Galton. Hypothyroidism: The Unsuspected Illness. New York: Harper & Row, 1976. Bell, David S. The Doctor's Guide to Chronic Fatigue Syndrome: Understanding, Treating, and Living with CFIDS. Cambridge, MA: Perseus Books, 1995. Berger, M. M., et al. "Relations between the selenium status and the low T3 syndrome after major trauma." Intensive Care Medicine 22 6 ; Jun 1996 ; : 57581 and tretinoin.

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Intravenous therapy is continued until the patient is able to tolerate oral therapy. Regimens for oral therapy are given in Table 4-3. Tetracycline may be used as an alternate to doxycycline. The regimen of tetracycline is an adult dose of 250 mg qid, and a pediatric dose of 5 mg kg qid, not to exceed 250 mg qid. Doxycycline and tetracycline are not to be used in children under 8. Alternate treatments include intravenous chloroquine, intramuscular FansidarR, mefloquine or halofantrine tablets crushed and mixed with water given via nasogastric tube, or artemisinin derivatives. Intravenous chloroquine is less toxic than qhinine or quinidine, but resistance to it is prevalent that it is not used for treatment of severe malaria cases. This applies even to areas without resistant strains of malaria. If oral therapy with mefloquine is chosen to complete the recommended 7 days of therapy, delay the intial dose for 12 hours after the last dose of quinidine or quinine. Halofantrine is a newly licensed drug developed by the Walter Reed Army Institute of Research. It should not be used in patients who developed P. falciparum infections while on mefloquine prophylaxis because parasite resistance to both drugs is similar. In addition, fatalities have occurred when halofantrine has been used for treatment in patients who received mefloquine prophylaxis. Intramuscular FansidarR a combination drug containing sulfadoxine and pyrimethamine ; has been shown to clear parasitemia as quickly as chloroquine, but hypersensitivity reactions to sulfonamides are common and cause complications. Artemisinin, a compound known as qinghaosu in China, has been used with great success there and in trials in Thailand. It is available as heterogeneous compounds in suppository, intravenous, and tablet forms. "Radical" Cure. To prevent relapse, P. vivax and P. ovale infections need to be treated to eradicate tissue schizonts persistent liver cell stages known as hypnozoites ; . This is known as "radical" cure, and currently the only available effective drug is primaquine. It is a potent oxidant, and can cause severe hemolytic anemia in G-6-PD deficient patients. Therefore, before treating with primaquine, the G-6-PD status of patients must be checked, and an appropriate dosage regimen selected. Radical cure dosage schedules are listed in Table 4-4 and retrovir. Rain metastases occur in a variety of different clinical settings, ranging from a single metastasis without extensive extracranial disease to multiple brain metastases with widespread systemic disease. In this thorough review, Drs. Nguyen and DeAngelis discuss the supportive medical therapies and definitive treatment options available to care for patients with brain metastases. Since patients with brain metastases are a heterogeneous group, therapy for brain metastases should be tailored to the specific clinical circumstances of each patient, for example, quinien leg cramp.

J assoc nurses aids care complementary medicine use among people living with hiv aids in victoria, australia: practices, attitudes and perceptions and rifater. The taste sensor electronic tongue, e-tongue ; can detect taste in a manner similar to human gustatory sensation. Taste substances cause changes in electric charge density of the lipid polymer membrane surface and or ion distribution near the surface of the membrane of the sensor. The total electric change is given as the response membrane electric potential for the substance tested. The response electric potential is different for substances possessing different taste qualities in each membrane and differs from one membrane to the other. Thus, taste information is acquired as a pattern of membrane potentials 3 ; . The output of the electronic tongue is the taste quality of the formulations tested and their intensity compared either to established standards e.g. assessment of bitterness using quinine hydrochloride or caffeine solution at different concentration levels ; or other references e.g. the formulation containing the active compound to be tested without any tasting masking agents ; . The methodology may be applicable to many paediatric dosage forms 1, 2 ; . The procedure is comparatively inexpensive and easy to conduct. In addition to taste evaluation during drug product development, taste sensors would also be useful in screening new substances for bitterness and monitoring the stability of taste over time. 3 Qualitative evaluation of the taste by a taste panel. Conducted at the end of the first quarter, it surveyed 100 hematologists and medical oncologists from across the country and rifampin. Underlying fear or skepticism about preventive medications may consciously or subconsciously affect the likelihood of a patient taking her doses regularly. Inappropriate expectations about the rapidity or extent of therapeutic effect may lead to premature discontinuation of a potentially successful drug because it did not reduce the headaches quickly enough or resolve them altogether. Untoward effects, such as drowsiness, weight gain, or reduced exercise tolerance, may not be significant enough in themselves to require discontinuation of the drug, but may reduce the patient's motivation to take it regularly. Because many individuals experiencing problematic headache are otherwise healthy, they are not accustomed to taking daily preventive medication and may simply forget. Patient education regarding the concept of preventive treatment as well as specific drug information may ease fears and improve commitment. Providing a medication dose schedule and having the patient keep a headache diary that records medication doses can help compliance as well. The overuse of abortive analgesic medication can complicate baseline headache by creating rebound phenomena and abuse syndromes, as well as potential for secondary organ involvement, such as GI, hepatic, and renal disease. It is basic instinct to seek escape from pain, and it is not uncommon for patients to take more over-the-counter OTC ; or prescription medication than directed. With a long history of headache, you may find the medicine cabinet full of different OTC preparations. In going from physician to physician for headache care, patients may collect a comparable array of prescribed medications. In an effort to obtain relief from severe or persistent headaches, some patients have secured more than one source of "rescue" medication. Guidelines and strict limitations for these "controlled" medications must be established. Patients need to know how much is safe to take per day and how many days per week are appropriate--and why. These instructions and limitations, written directly on the prescription, emphasize to the patient and the pharmacist ; your determination to closely monitor drug use. Discriminating practices that count doses and account for medications prescribed help to identify overuse problems. If the patient is overusing medication, it may be an indication that the management program is inadequate, and attention can be directed to a more effective preventive program or a more appropriate symptomatic treatment. Medication, of course, is only one aspect of the care plan for many headache patients. Follow-through on behavioral recommendations reduce caffeine, avoid alcohol, don't sleep too late on weekends ; and nonpharmacologic interventions biofeedback, family counseling, physical therapy ; should also be emphasized. Regular review of these aspects as part of the prescribed treatment emphasizes your commitment to a comprehensive approach to care. 5. Some kinds of bacteria are present on the breast and nipple area all the time. These bacteria are not harmful to your baby and so do not need to be washed off before breastfeeding. However, the bacteria on your hands and that which can collect on your pumping equipment can contaminate your milk. Just as you wash and scrub your hands before going into the nursery to visit your baby, washing your hands before you express your milk and keeping the pumping equipment clean is important. Whenever you express your milk to be stored and used later, you need to follow these steps: Have handy the breast pump if you use one ; and a sterile bottle to hold the milk. , Wash your hands well. Use a brush to clean under your nails. Rinse your breasts with clear water. Dry the nipple areas, then the breasts, with a clean towel Pump each breast about 10 -15 minutes, or a few minutes after the milk flow stops. Moms using pumps with two collection systems can pump both breasts at once. Massage your breasts during pumping to help them empty. Pour the milk you collect into the sterile bottle * . Label it with your baby's name, the date and time you collect it and the names of any medications you may be taking and risperidone and quinine, because quinine tonic water.
8.3.42 Opiate Poisoning 8.3.43 Organophosphate Poisoning 8.3.44 Wuinine Poisoning 8.3.45 Serotonin Reuptake Inhibitors - Poisoning 8.3.46 Sulfonylureas - Poisoning 8.3.47 Theophylline Poisoning. Crist gave me the quinine for the babesia and combined it with the clindamycin and roxithromycin.

John Blenkinsopp Symptoms in the Pharmacy Final Proof 7.7.2004 2: 26pm page 128. The community's perspective on school nutrition and health programs. Information on the perceptions of students, parents, teachers, health workers, and others who need to be directly involved in a school nutrition or health program includes perceptions about what needs to be done and about the acceptability and capability of the school system as a source of health and nutrition education and services. The community's willingness and capacity to support school nutrition and health programs. The issues here are whether students and parents would be willing and able to contribute resources to the development of services and what the scale and type of this contribution would be. The potential for children to be active participants in improving their nutrition, health, and education. This assessment requires an understanding of existing knowledge, attitudes, beliefs, and practices about health and education. Our Coatings business is the world leader. It embraces most of the markets in both consumer and industrial applications for paints and coatings. We are focusing on growth in the emerging markets of Asia, Eastern and Central Europe, and South and Central America through autonomous development and acquisitions. We will also continue to enhance our presence in the mature markets through selected acquisitions. Our ambition is to remain the world leader in coatings and consolidate our leadership positions in all our product markets and key geographic regions. We intend to participate in the consolidation of the coatings industry, which we believe is inevitable as our supplier and customer bases strengthen globally. Our global scale allows us to further develop our leading positions in technology. We are progressively increasing our investments in R&D towards 3.5% of revenues. Our increasing innovation efforts will allow better differentiation of our activities in the highly competitive markets in which we operate. We are also using our scale in purchasing of raw materials to secure our margins. Terbinafine and exacerbation of lupus erythematosus Introduction Terbinafine Lamisil ; is an antifungal agent approved for the Dutch market in 1991. Terbinafine is indicated for the treatment of tinea capitis and dermal fungal infections by tinea corporis, tinea cruris or tinea pedis, and for treatment of onychomycosis, caused by dermatophyts [1]. The most frequent adverse drug reactions mentioned in the SPC are: gastro-intestinal symptoms, non-serious skin reactions erythema, urticaria ; and musculoskeletal reactions arthralgia, myalgia ; . Rare cases of Erythema Multiforme, Stevens Johnson syndrome Toxic Epidermal , Necrolysis, anaphylactic reactions and of taste alterations, hepatic effects, hematologic disorders and alopecia are described as well. The SPC does not mention Lupus Erythematosus LE ; as a possible adverse drug reaction [1]. Lupus Erythematosus refers to a chronic autoimmune disease with unknown etiology and a variety of symptoms. It is characterized by the presence of anti-nuclear antibodies ANA ; . Most commonly seen symptoms are fatigue, arthritis, muscle pain and skin rashes. Reports Up to December 2003, the Lareb database contains a total of 22 reports of Lupus Erythematosus as a suspected adverse drug reaction. Four reports refer to a LE-like skin reaction, associated with the use of terbinafine Table 1 ; . Patient A is a 34-year-old female, with a medical history of SLE. She used terbinafine for the treatment of hallux mycosis. After 3 months she developed itchy red spots on chest, back and arms, specified as: blurry bounded, lenticular to numular, big erythematous laesions. Immunofluorescence tests were indicative for exacerbation of existing LE. Upon discontinuation of terbinafine and local treatment with clobetasol the patient recovered from this skin reaction. Extensive concomitant medication was used. Patient B is a 70-year-old female. She used terbinafine for 2 months and then developed a LE like skin reaction, first on the chest, later also on trunk, extremities and face. Immunofluorescence tests were indicative for SCLE subacute cutaneous LE ; . Upon discontinuation of terbinafine and local treatment with clobetasol patient improved. In retrospect, the patient had possibly had similar symptoms not related to terbinafine ; several years before. Patient C is a 26-year-old female with SLE. After 6 weeks of terbinafine use for onychomycosis, she developed a SCLE-like skin reaction, described as slightly raised erythematous spots spread over the whole body; lenticular to numular erythematous-papular plaques. Pathological anatomical examination confirmed the assumption of SCLE luxation. Terbinafine was discontinued and the patient was at first treated with cetirizine, followed by prednisone, whereafter the symptoms disappeared. Patient D is a 24-year-old female, who used terbinafine for onychomycosis. After 3 months she developed CDLE chronic discoid LE ; -like skin disorders. Additional histological examination including immunofluorescence ; demonstrated an image consistent with LE. After discontinuation of terbinafine and treatment with hydroxychloroquinine and locally applied ; clobetasol the patient partly recovered. Upon inquiry it appeared that she had also experienced LE -like skin reactions not related to terbinafine ; in the past.
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