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Q EKG monitor q 12 Lead EKG n V4R should be manually evaluated if any ST elevation in leads II, III, or aVF q IV 0.9% NaCl KVO q Unstable, with serious signs or symptoms n ventricular rate greater than 150 beats per minute may give brief trial of medications see STABLE OR BORDERLINE below ; refer to CARDIOVERSION TREATMENT GUIDELINE See Page 137 ; n immediate cardioversion seldom needed for rates less than 150 beats per minute see STABLE OR BORDERLINE below ; q Stable or borderline n further treatment not recommended if patient stable n vagal maneuvers n adenosine phosphate Adenocard ; 6 mg IVP over 13 seconds As rapid as possible in the most proximal IV port. ; after 12 minutes, 12 mg IVP over 13 seconds; may repeat once q Narrow QRS complex n blood pressure low or unstable refer to CARDIOVERSION TREATMENT GUIDELINE See Page 137 ; n consider diltiazem Cardizem ; by EDP consult n verapamil Isotpin ; 2.55.0 mg IVP over 12 minutes after 1530 minutes, verapamil Isopyin ; 510 mg IVP over 12 minutes synchronized cardioversion q Wide QRS complex n refer to W IDE COMPLEX T ACHYCARDIA OF U NCERTAIN T YPE T REATMENT GUIDELINE See Page 145 and
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Running Title: Blockade of CB1 receptors potentiates L-DOPA effects Corresponding author: Stella M. Papa, M.D. Department of Neurology, Emory University. 6000 WMRB, 101 Woodruff Circle. Atlanta, Georgia 30322, US. Tel: + 1-404-727-8307 O ; , Fax: + 1-404-727-9294, E-mail: spapa emory Total number of text pages: 40 Number of Tables: 3 Number of figures: 6 Number of references: 40 Number of words in Abstract: 242 Number of words in Introduction: 709 Number of words in Discussion: 1094 Abbreviations: CE, 1-[7- 2-Chlorophenyl ; -8- 4-chlorophenyl ; -2-methylpyrazolo[1, 5a]-[1, 3, acid amide benzenesulfonate; CP-55940 [ 1R, 3R, 4R ; -3-[2-hydroxy-4- 1, 1dimethylheptyl ; phenyl]-4- 3-hydroxypropyl ; cyclohexan-1-ol]; L-DOPA, L3, 4dihydroxyphenylalanine; CB1, Cannabinoid type 1 receptor; 2AG, 2-arachidonyl glycerol; GABA, gamma-aminobutyric acid; 5-HT1B, serotonin receptor 1B; GPe, globus pallidus external segment; GPi, globus pallidus internal segment; SNr, substantia nigra pars reticulata; PD, Parkinson's disease; LID, L-DOPA-induced dyskinesias; MPTP, 1-methyl-4-phenyl-1, 2, 3, HPLC, High.
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