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The main benefits of equifem-balance reside in its soy isoflavone content and include fewer menopausal symptoms such as hot flushes and night sweats ; , a reduced risk of cardiovascular disease and osteoporosis. Said nagata: there is a hypothesis that isoflavone, which is an element contained in great quantity in soybeans, may have good a effect on blocking cancer. Aware of a meeting organized by the Organization for Economic Co-operation and Development, held in Aussois, France, in March 1997, which is about to be published. Hence they present an outdated view of the use of substantial equivalence, while their characterization of this tool as the outcome of an international conspiracy to foist genetically modified GM ; foods on a gullible public is beyond belief. Do Millstone et al. really believe in a worldwide conspiracy? They have no evidence for this assertion. Second, by such accusations, Millstone et al. denigrate the whole regulatory process and all the hard-working academics who make up the British regulatory committees. Throughout their article, they reveal their ignorance of the way the regulatory process works. Substantial equivalence is a tool only: the `first cut' at the decision-making rather than a quick solution, as the authors infer. I was chairman of the Advisory Committee on Novel Foods and Processes ACNFP ; from 1989 to 1997, and we never received any political or commercial pressure when making decisions. I totally reject the slur on our integrity. Finally, Millstone et al. are wrong in what they say about GM soya. They imply that a herbicide that has no effect on the target enzyme, and that does not persist in the plant, has far-reaching effects on intermediary metabolism. If the herbicide does not affect its target, how can it affect the plant? Not only is this idea bizarre, it is wrong: GM beans have been analysed after treatment with herbicide and their composition is unaffected24. Millstone et al. are also wrong to say that treatment with herbicide alters the isoflavone content; they do quote one paper reporting some variation but ignore others showing that this difference is well within the normal range of isoflavone content4 . More than 1, 400 compositional analyses of Roundup Ready soya beans have been conducted, showing that there are no significant differences in the key soya bean nutrients and anti-nutrients; these data have been reviewed by the ACNFP. The authors use the literature selectively to make their point, which is not good enough for any scientific journal. I contend that these data establish that GM soya beans are as safe as conventional soya beans. This conclusion was reached by the ACNFP after a thorough safety assessment, using substantial equivalence as a key safety assessment approach. This conclusion has been confirmed by regulatory agencies in the 13 countries that have approved these GM soya beans. This food has been used commercially for four years, and 300 million Americans are currently eating it with no sign of a problem.

1. Anuradha M, Pullaiah T. Propagation studies of red sanders Pterocarpus santalinus L.f. ; in vitro an endangered taxon of Andra Pradesh, India. Taiwania 1999; 44: 311-24. Keshav Reddy K, Srivasuki KP. Vegetative propagation of red sanders Pterocarpus santalinus L.f. ; . Indian Forester 1990; 116: 536-9. Chopra RN, Nayar SL, Chopra IC. Glossory of Indian Medicinal Plants. New Delhi: C.S.I.R. Publications; 1956. 4. Anonymous. The Wealth of India. New Delhi: C.S.I.R. Publications; 1969. 5. Krishnaveni KS, Srinivasa Rao JV. A new isoflavone glucoside from. The effects of running exercise on the body weight of OVX rats was described differently. Nordsletten et al.5 has reported that exercise with 27m minute intensity might restrained the weight of OVX rats's increase. Peng et al. 7 has reported that exercise with 18 m minute intensity could reduce the gain weight of OVX rats. Zhang et al. 8 has reported that exercise with 20 m minute intensity had not restrainable effect on the weight of OVX rats's increase. And compare with quiet group, moderate intensity rats weight' increase was higher than OVX-C group. The effects of isoflavone on the body weight of OVX rats was reported consistently. Fanti et al.9 has reported that the body weight of genistein group was increased higher than the Sham and lower than Cont group. Shi et al. 10 has reported that the body weight of IF group was higher than Sham 42 days after the ovariectomy. Our study shows that 50 mg kg soybean isoflavone dosage and moderate exercise all would reduce the gain weight of OVX rats, the moderate exercise would be more remarkable. p 0.05 ; Ishimi et al.11 has reported that genistein prevents bone loss caused by estrogen defieieney without exhibiting estrogenic action in the uterus. But phytoestrogens, including soybean isoflavones, have received considerable attention due to their possible effects as endocrine disrupters. According to our results, isoflavone extract from soybean hypocotyls was able to prevent OVX-induced bone loss without exhibiting estrogenic action in the uterus of OVX-IF rats. Bone remodeling activity is in contact with bone metabolism parameters. OVX-induced osteoporosis belongs to high conversion type, bone formation and bone resorption are all increased, but bone resorption is more remarkable. AKP and BGP are markers of osteogenesis, TRAP is markers of bone resorption. Our study shows that levels of BGP were not significantly among all the groups p 0.05 ; . And the levels of serum BGP of postmenopausal women were reported inconsistently.4, 12, 13 In our study, the AKP and TRAP activities for the OVX group were higher than that for the Sham group significantly p 0.01p 0.05 ; . That shows bone resorption in OVX rats was increased, it appeared compensative bone formation increase accompanying bone resorption's excessive. Compared with OVX, the AKP activities of the IF and EXE-IF groups were lower than that of the OVX group p 0.01 ; after 8 weeks, but the difference in EXE group was not remarkable. It shows the isoflavone have mostly effect on bone formation compared with exercise. So the mechanism of the isoflavone and exercise preventing bone loss in OVX rats may be different. Isoflavon prevented osteoporosis likely by restraining bone metabolize high turnover state!

The tablet may be crushed or split and isoniazid. A study by Hall et al98 investigates the benefits of continued therapist contact in weight loss maintenance programs. Subjects were female, aged between 18 and 65 years, not pregnant, at least 20% overweight, but otherwise healthy. All the women participated in a 10 week behavioural weight loss program that entailed food and weight monitoring, the application of cognitive techniques, and group support. Following this, they were allocated to one of three maintenance interventions: minimal contact, monitoring minimal contact, or continued contact.

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This study was designed to evaluate the sensitivity and specificity of simplify D-dimer to rule out pulmonary embolism in patients presenting to the emergency department with pleuritic chest pain. Simplify D-dimer is a rapid, bedside d-dimer test. This was a prospective diagnostic study. Seven hundred ninety-nine patients were assessed for inclusion into the study. Of these, 277 were excluded and 97 declined to participate. A total of 425 patients participated in the study. A total of 120 patients tested positive on the simplify D-dimer, and of those 18 were positive for pulmonary embolism. A total of 297 patients tested negative on the simplify D-dimer and of those, 4 had pulmonary embolism. The sensitivity was 81.8%, and the specificity was 74.2%. The positive predictive value was 15%, The negative predictive value was 98.6%. When the simplify D-dimer was combined with pre-test probability scoring, the sensitivity of the combined test was 90.9%, and the specificity of the combined test was 68.9%. The authors conclude that the Simplify D-dimer is not sufficiently accurate to exclude the diagnosis of pulmonary embolism in all patients presenting to the ED with pleuritic chest pain. Hogg et al, Annals of Emergency Medicine, October, 2005. Ann Emerg Med 2005; 46: 305-10 Editors note It should be re-emphasized that this is for the one bedside d-dimer test. MSB and vasodilan, for instance, soy isoflavones hair.

Risk of osteoporosis. Soy isoflavone has proven to be effective in preventing the bones from weakening. In comparison to other high quality proteins, soy protein causes less calcium to be excreted in the urine. Cancer: Soybean isoflavones may work several ways to reduce cancer risk or to interfere with the cancer process. According to studies, just one serving of soy per day may reduce the risk of cancer. Soybeans are rich in several anti-cancer causing agents. Heart Health: Studies conducted over the past 25 years have shown that soy protein lowers cholesterol. Soy foods may play a role in a heart-healthy diet for the following reasons: Soybeans are very low in saturated fat and like all plant foods are cholesterol-free. Soy protein directly lowers blood cholesterol. Soy may interfere with oxidation of LDL bad ; cholesterol. Diabetes: More recently, scientists have suggested that soy foods may benefit those with diabetes in the following ways: Soybeans have a low blood sugar index. Soybeans are rich in soluble fiber. Soy protein may help to reduce blood cholesterol levels. Soy protein may improve renal function. Kidney Health: Soy foods can easily help renal patients meet their elevated protein needs since it is of the highest quality, but it does not appear to have the same detrimental effects on kidney function as animal proteins. The antioxidant effects of isoflavone help balance cholesterol in the blood, decreasing levels of ldl cholesterol and increasing or maintaining levels of hdl cholesterol and ketorolac.

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As permitted by Section 230 of the Companies Act 1985, the profit and loss account of the company is not presented. The consolidated statement of total recognised gains and losses comprises: the realised profit attributable to shareholders as reflected in the consolidated profit and loss account the unrealised gain or loss in the value of the Group's overseas net assets, less related foreign currency borrowings, attributable to currency movements over the period. The reconciliation of movements in equity shareholders' funds comprises the items contributing to the increase or decrease over the period in shareholders' funds. Such items include: the total recognised gains and losses for the period dividends paid and proposed the proceeds of shares issued during the period the cost of shares purchased for cancellation under the share buy-back programme changes to goodwill, arising on acquisitions prior to 1st January 1998, which has been set directly against reserves. [13] Bray GA. Drug treatment of obesity. Rev Endocr Metab Disord 2001; 2: 403 [14] Gastrointestinal surgery for severe obesity: National Institutes of Health Consensus Development Conference Statement. J Clin Nutr 1992; 55 suppl 2 ; : S615S619. [15] Martin LF, Tan TL, Horn JR, et al. Comparison of the costs associated with medical and surgical treatment of obesity. Surgery 1995; 118: 599 [16] Fisher BL, Barber AE. Gastric bypass procedures. Eur J Gastroenterol Hepatol 1999; 11: 9397. [17] Schauer PR, Ikramuddin S. Laparoscopic surgery for morbid obesity. Surg Clin North 2001; 81: 11451179. [18] Schauer PR, Ikramuddin S, Gourash W, et al. Outcomes after laparoscopic Roux-en-Y gastric bypass for morbid obesity. Ann Surg 2000; 232: 515529. [19] Nguyen NT, Goldman C, Rosenquist CJ, et al. Laparoscopic versus open gastric bypass: a randomized study of outcomes, quality of life, and costs. Ann Surg 2001; 234: 279 [20] Schweitzer MA, Broderick TJ, Demaria EJ, Sugerman HJ. Laparoscopic-assisted Roux-en-Y gastric bypass. J Laparoendosc Adv Surg Tech A 1999; 9: 449 [21] American Society for Bariatric Surgery. Membership survey. Gainesville, FL: American Society for Bariatric Surgery, 1999. [22] Balsiger BM, Poggio JL, Mai J, et al. Ten and more years after vertical banded gastroplasty as primary operation for morbid obesity. J Gastrointest Surg 2000; 4: 598 [23] Sugerman HJ, Starkey JV, Birkenhauer R. A randomized prospective trial of gastric bypass versus vertical banded gastroplasty for morbid obesity and their effects on sweets versus non-sweets eaters. Ann Surg 1987; 205: 613 [24] Mason EE. Vertical banded gastroplasty for obesity. Arch Surg 1982; 117: 701706. [25] MacLean LD, Rhode BM, Forse RA. Late results of vertical banded gastroplasty for morbid and super obesity. Surgery 1990; 107: 20 [26] Eckhout GV, Willbanks OL, Moore JT. Vertical ring gastroplasty for morbid obesity: five year experience with 1, 463 patients. J Surg 1986; 152: 713716. [27] Olbers T, Lonroth H, Dalenback J, et al. Laparoscopic vertical banded gastroplasty: an effective long-term therapy for morbidly obese patients? Obes Surg 2001; 11: 726 [28] Morino M, Toppino M, Bonnet G, et al. Laparoscopic vertical banded gastroplasty for morbid obesity. Surg Endosc 2002; 14: [29] Wilkinson LH, Peloso OA. Gastric reservoir ; reduction for morbid obesity. Arch Surg 1981; 116: 602 [30] Szinicz G, Schnapke G. A new method for surgically controlling obesity. Acta Chir Austraica 1982; 43 suppl ; : 48. [31] Kuzmak LI. A review of seven years' experience with silicone gastric banding. Obes Surg 1991; 1: 403 [32] Fielding GA, Rhodes M, Nathanson LK. Laparoscopic gastric banding for morbid obesity: surgical outcome in 335 cases. Surg Endosc 1999; 13: 550 [33] Belachew M, Legrand M, Vincent V, et al. Laparoscopic adjustable gastric banding. World J Surg 1998; 22: 955963. [34] Dargent J. Laparoscopic adjustable gastric banding: lessons from the first 500 patients in a single institution. Obes Surg 1999; 9: 446 [35] O'Brien PE, Brown WA, Smith A, et al. Prospective study of a laparoscopically placed, adjustable gastric band in the treatment of morbid obesity. Br J Surg 1999; 86: 113118. [36] Belachew M, Belva PH, Desaive C. Long-term results of laparoscopic adjustable gastric banding for the treatment of morbid obesity. Obes Surg 2002; 12: 564 [37] Favretti F, Cadiere GB, Segato G, et al. Laparoscopic banding: selection and technique in 830 patients. Obes Surg 2002; 12: 385390. [38] Angrisani L, Alkilani M, Basso N, et al. Laparoscopic Italian experience with the LAP-BAND. Obes Surg 2001; 11: 307310. [39] Weiner R, Wagner D, Bockhorn H. Laparoscopic gastric banding for morbid obesity. J Laparoendosc Adv Surg Tech A 1999; 9: 2330 and ketotifen!

GSPE belongs to a flavonoid group, and that used in the present study was a natural extract from the seeds of Vitis vinifera grapes10, 19, and contained 90% proanthocyanidins. The 6 major subclasses of flavonoids include flavones, flavonols, flavanones, catechins, anthocyanidins, and isoflavones2, 20, while proanthocyanidins are a polymer of catechin. Although beneficial bone responses to flavonoid therapy are well reported in studies using ipriflavone, which is abundant in beans and has been used to inhibit bone resorption as an inducer of isoflavone1-5, the effects of proanthocyanidins in those responses have not been well established. Proanthocyanidins are safe10 to consume and known to possess a broad spectrum of pharmacological, medicinal, and therapeutic properties21. Further, several GSPE mixtures have been reported, including a niacin-bound chromium and GSPE mixture6, as well as a pancreatic enzyme and GSPE mixture, that was used as an analgesic22. In the present study, GSPE was added to a standard diet and given to rats. An.

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RealAge ; If your New Year's resolution to lose weight has you eyeing the natural weight loss pills at the drug store, look the other way. Although we've heard much about the dangers of ephedracontaining diet pills, ephedra-free diet pills can be hazardous to your health as well. Ones that contain bitter orange, caffeine, or other natural stimulants may cause dangerous spikes in heart rate and blood pressure. Shed excess pounds with a sustainable program of healthy eating and exercise. Vitamins and supplements are not regulated in the same way as medications. Just because they are available over-the-counter or claim to contain all-natural ingredients doesn't mean that they are safe. The same is true of diet pills. While products containing the stimulant ephedra are now banned, weight-loss aids may contain other stimulants that increase the risk of heart attack and stroke by raising heart rate and blood pressure. In a study comparing the effects of two weight-loss aids, participants who took one dose of a diet pill containing bitter orange Citrus aurantium ; experienced an increase in heart rate of more than 11 beats per minute while people who took a diet pill containing bitter orange, caffeine, and other ingredients experienced an increase of almost 17 beats per minute as well as a rise in blood pressure. Aim for long-term health over short-term gains by eating a nutrient-rich, calorie-poor diet and boosting your exercise efforts, for example, isoflavones skin. Phenoxodiol 2H-1-benzopyran-70, 3- hydroxylphenyl ; is a pharmacophore of the naturally-occurring plant isoflavone, genistein. These plant hormones regulate plant cycle kinetics and death and may have similar effects in animals [1]. The anti-cancer effect of isoflavones was initially suggested by the observation of an inverse relationship between dietary isoflavone intake and cancer incidence [12]. Genistein is a pan inhibitor of tyrosine kinases in human tumor cells, and along with certain other members of the family of plant flavonoids such as quercetin and rohitukane source of flavopiridol ; , exerts modest anti-cancer activity against a wide range of human and animal cancers including melanoma [2, 3], leukemias [4, 5], breast cancer [6, 7], gastrointestinal cancers [8], prostate cancer [9, 10] and other solid tumors [11]. Phenoxodiol is an analogue of genistein that delivers substantially greater anti-tumor potency and and lamotrigine.

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Non Steroidal Estrogens of Dietary Origin, " Setchell K.D., Estrogens in the Environment, John A McLaughlin, ed. Elsivir, 1985: 69-83. -- "Since as little as 8 mg of genistein and 10 mg of daidzein are sufficient to initiate uterotrophic effects in mice, it is not surprising that the relatively large amounts of isoflavones present in soy protein will readily explain the previously observed estrogenic effects in animals . The effects of plant estrogens in man should, however, be of some concern since the newborn infant will be subject to chronic exposure to soyamilk, in some cases for up to two years . this situation could be considered analogous to sheep grazing on clover.

Setchell et al. 1984 ; . This may explain why no equol could be found in urine of subjects who ingested only a single dose of soymilk. Isoflavones may be degraded as well as metabolized in the intestine. The C-ring of flavonoids can be cleaved by human intestinal bacteria, and 5 mg of quercetin, one of the flavonoids, can be completely converted to a monophenolic compound 3, 4-dihydroxyphenylacetic acid ; within about 3-4 h in a prereduced brain-heart infusion broth under anaerobic conditions Winter et al. 1989 ; . Isoflavones are analogous to the flavonoids, with the aromatic B-ring linked to carbon 3 of the C-ring instead of carbon 2. Therefore, it is very likely that human intestinal bac teria can also metabolize ingested isoflavones to a great extent. This may be why only 15-20% of isofla vones were recovered intact in urine and feces. Developing methods to measure monophenolic and other diphenolic lsoflavone breakdown products may be important because some monophenolic com pounds"such as methyl p-hydroxyphenylacetate, a metabolite of both exogenous flavonoids and tyrosine"are inhibitors of hormone-dependent cancer cell growth and proliferation. This compound has higher affinity for the nuclear type II binding site than does estradiol. This type II binding site has been suggested to be involved in cell growth regulation by estrogenic hormones. This metabolite can block es tradiol stimulation of uterine growth in vivo and inhibit the growth of MCF-7 human breast cancer cells in vitro Markaverich et al. 1988 ; . In the future, the cancer-protective potential of isoflavones may be estimated from plasma concentra tions. Much work remains to be done to determine effective plasma isoflaovne concentrations. Average plasma concentration of total isoflavones reached 4.4 tmol Lat 6.5 h after a dose of 2.0 mg isoflavones kg body wt Table 4 ; . A study of 3T3 cell inhibition of production of inositol phosphates, key intracellular signals that mediate tumor promotion, showed an ICso for daidzein of 8 rnol Land for genistein of 2.2 xmol L, when inositol phosphate production was stimulated by aluminum tetrafluoride Higashi and Ogawara 1992 ; . Thus, our data suggest that human dietary exposure to isoflavones could provide cir culating levels of isoflavones that might be of potential benefit with respect to cancer development. From this study, we conclude that absorption and excretion and plasma concentration of isoflavones in humans depend upon the dose given. Systemic bioavailability of daidzein is greater than that of genistein, which suggests that a greater focus on the biological effects of daidzein may be warranted. Al though bioavailability of isoflavones may be, on average, only 15%, probably due to a first-pass effect and subsequent intestinal bacterial degradation, enough isoflavones may still be absorbed from soymilk to exert potentially beneficial biological ef fects and levothyroxine.
P-M-421 CORTICAL NEURONS AGGREGATE IN RESPONSE TO PLASMIN FORMED AT THEIR SURFACE BY TPA E. Angles-Cano FR ; , B. Ho-Tin-Noe * , H. Enslen, J. Corsi, R. Lijnen INHIBITION BY SOY ISOFLAVONES OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE FUNCTION S. Rotondo IT ; , K. Krauze-Brzsko, S. Manarini, N. Martelli, R. Pecce, V. Evangelista, M. Donati, C. Cerletti * PLATELET BUT NOT LEUKOCYTE ACTIVATION IS A PREREQUISITE FOR PLATELET-LEUKOCYTE INTERACTION IN HUMAN WHOLE BLOOD B. Izzi * IT ; , A. Pampuch, G. De Gaetano, C. Cerletti ACTIVATED PLATELETS ENHANCE THE ADHERENCE TO AND INVASION OF ENDOTHELIAL CELLS BY STAPHYLOCOCCUS AUREUS B. E. Kehrel DE ; , S. Niemann * , C. Heilmann, G. Peters, H. K. Van Aken CYTOKINE-INDUCED MONOCYTE-ENDOTHELIAL CELL INTERACTIONS: EFFECT ON PAI-1 LEVELS J. Orbe ES ; , M. Valgan, J. A. Rodriguez, M. Belzunce, J. A. Paramo * DETERMINANTS OF PLATELET AGGREGATE FORMATION WITH EITHER POLYMORPHONUCLEAR LEUKOCYTES OR MONOCYTES IN HUMAN WHOLE BLOOD A. Pampuch * IT ; , B. Izzi, S. Costanzo, B. Vohnout, L. Iacoviello, M. Donati, C. Cerletti, G. De Gaetano.

Nonhormonal Therapies Phytoestrogens Research in the area of soy as a hormone replacement therapy or a synergetic to hormone replacement therapy is still in its infancy. Soy isoflavones have been hypothesized to exert hormone effects on peri- and postmenopausal women. Hot Flashes Although it is believed that soy isoflavones act as estrogen agonists in the low-estrogen makeup of postmenopausal women, which may benefit vasomotor symptoms, findings on the effects of soy on hot flashes are mixed, and studies suggest that soy is likely to have no more than a modest effect. The majority of presentations and posters at the 1999 International Symposium showed no positive results. Difficulty interpreting studies is compounded by the fact that isoflxvone form, standardization and dose vary widely. Cholesterol The cholesterol lowering effect of soy protein, especially from foods, is well-documented. In the fall of 1999, the FDA ruled that foods containing 6.25 g serving or more of soy protein are eligible to bear a health claim stating that soy protein, as part of a diet low in saturated fat and cholesterol, may reduce the risk of coronary heart disease and lithobid.

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The fees for each stage of Graduated Licensing are listed on the following chart. The fees for tests apply each time a test is taken e.g., if a new driver fails a test and has to take it again, the test fee must also be paid again ; . If you fail to attend your road test appointment without providing at least 48 hours cancellation notice or a valid reason acceptable to ICBC, $25 will be added to your next road test fee, for example, isoflavones breast cancer.

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Rh incompatibility, familial non-hemolytic jaundice ; the side effects listed below are not experienced by everyone who takes this medication. PSA has held at 0.4 for over a year. I believe that this may be helped by taking soy isoflavones. If the PSA rises again, my next option would be some sort of hormonal therapy. In the meantime, my spouse and I are leading a very active life--biking extensively, social with family and friends, traveling, etc. LIFE IS GOOD.

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12 women consumed 60 mg isoflavones daily for 10-14 days. A residual postmenopausal effects was seen in postmenopausal subjects. "In one premenopausal woman, enhanced LH secretion was observed after soy treatment, suggesting there may be subpopulations of women are highly sensitive to isoflavones." - : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 11861976&dopt Abstract. 30 ; the subjects were given 110 mg a relatively high dose given divided in two daily doses ; of extracted soy isoflavones or placebo daily for six months. Acid reducer oral interactions if you are taking this medication under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Major constituents: daidzein, daidzin, genistein, genistin, glycitein, glycitin soy isoflavone, a sort of bioflavonoid, mainly located in the cotyledon and hypocotyl of the bean seeds. CALCIUM CURRENTS IN DEVELOPING RABBIT SINUS NODE 15. Fermini B and Nathan RD. Removal of sialic acid alters both T- and L-type calcium currents in cardiac myocytes. J Physiol Heart Circ Physiol 260: H735H743, 1991. 16. Furukawa T, Ito H, Nitta J, Tsujino M, Adachi S, Hiroe M, Marumo F, Sawanobori T, and Hiraoka M. Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes. Circ Res 71: 1242 1253, Gomez JP, Potreau D, Branka JE, and Raymond G. Developmental changes in Ca2 currents from newborn rat cardiomyocytes in primary culture. Pflugers Arch 428: 241249, 1994. Haddock PS, Coetzee WA, and Artman M. Na Ca2 exchange current and contractions measured under Cl -free conditions in developing rabbit hearts. J Physiol Heart Circ Physiol 273: H837H846, 1997. 19. Hagemann D, Hoch B, Krause EG, and Karczewski P. Developmental changes in isoform expression of Ca2 calmodulin- dependent protein kinase II delta-subunit in rat heart. J Cell Biochem 74: 202210, 1999. Hagiwara N, Irisawa H, and Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol Lond ; 395: 233253, 1988. Hata T, Noda T, Nishimura M, and Watanabe Y. The role of Ca2 release from sarcoplasmic reticulum in the regulation of sinoatrial node automaticity. Heart Vessels 11: 234241, 1996. Hewett KW and Rosen MR. Developmental changes in the rabbit sinus node action potential and its response to adrenergic agonists. J Pharmacol Exp Ther 235: 308312, 1985. Hofmann F, Lacinova L, and Klugbauer N. Voltage-dependent calcium channels: from structure to function. Rev Physiol Biochem Pharmacol 139: 3387, 1999. Huynh TV, Chen F, Wetzel GT, Friedman WF, and Klitzner TS. Developmental changes in membrane Ca2 and K currents in fetal, neonatal, and adult rabbit ventricular myocytes. Circ Res 70: 508515, 1992. Kato Y, Masumiya H, Agata N, Tanaka H, and Shigenobu K. Developmental changes in action potential and membrane currents in fetal, neonatal and adult guinea-pig ventricular myocytes. J Mol Cell Cardiol 28: 15151522, 1996. Kumar R, Joyner RW, Komalavilas P, and Lincoln TM. Analysis of expression of cGMP-dependent protein kinase in rabbit heart cells. J Pharmacol Exp Ther 291: 967975, 1999. Kumar R, Namiki T, and Joyner RW. Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells. Cardiovasc Res 33: 573582, 1997. Lader AS, Kwiatkowski DJ, and Cantiello HF. Role of gelsolin in the actin filament regulation of cardiac L-type calcium channels. J Physiol Cell Physiol 277: C1277C1283, 1999. 29. Lee JH, Gomora JC, Cribbs LL, and Perez-Reyes E. Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H. Biophys J 77: 30343042, 1999. Lei M, Brown HF, and Noble D. What role do T-type calcium channels play in cardiac pacemaker activity? In: Low VoltageActivated T-Type Calcium Channels, edited by Tsien RW, Clozel J-P, and Nargeot J. Chester, UK: Addis International, 1998, p. 103109. 31. Leuranguer V, Monteil A, Bourinet E, Dayanithi G, and Nargeot J. T-type calcium currents in rat cardiomyocytes dur!

The Archer Daniels Midland Company ADM ; have provided the Food and Drug Administration FDA ; with notice that it has determined that the substance soy isoflavone is generally recognised as safe GRAS ; . This notice was made in accordance with the FDA proposed rule `Substances Generally Recognized as Safe' 21 CFR Parts 170, 184, 186 and 570. In support of this notice, ADM have provided a document entitled `An information document reviewing the safety of soy isoflavones used in specific dietary applications'. In my opinion soy isoflavone or more correctly, the soy isoflavones ; should not be granted GRAS status. In fact given the current state of knowledge in the body of scientific literature it would make more sense, in terms of risk assessment, to prohibit the addition of soy isoflavones to foods. Further, manufacturers should act to minimise the exposure of the human and animal population to these compounds that appear to occur in all foods that contain soy protein. This opinion is based on my understanding of the scientific literature on soy isoflavones and some experience as a researcher in the field. I have read the ADM supporting document and have found that, as a scientific document, it is seriously lacking. Firstly, the document contains several important factual errors. Some of these errors were so blatant that it caused me to reflect on ADM's moral and legal obligation to present an accurate case to the FDA. Secondly, I noted that the references cited in the ADM document frequently misrepresented, and sometimes bore no relation to, the conclusions made by the authors cited. Thirdly, the ADM document does not present the full body of current scientific evidence regarding soy isoflavones. Several notable omissions exist in relation to the potential for soy isoflavones to cause breast cancer and thyroid disease. Finally, many of the conclusions reached in the ADM document are not based on factual evidence and logic but rather assumption and belief. As such the ADM document does not represent good science. These scientific deficiencies in the ADM document, and counter arguments, are detailed in the sections below.

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Drug-induced thrombotic thrombocytopenic purpura hemolytic uremic syndrome: a concise review. C.04.017. A fabricator shall keep necropsy records of all animals that die or are killed after having been use in the production of a drug. C.04.018. A fabricator shall immediately segregate, and report the fact to the Minister, any animal with actual or suspected vesicular stomatitis, foot and mouth disease, encephalomyelitis, infectious anaemia, glanders, anthrax, tetanus or any other serious infectious disease. Table 1. Emetogenic potential of chemotherapy agents Level 5 Frequency of emesis % ; * 90 Agent.

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