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Warnings precautions do not get this medicine in your eyes or on the inside of your nose or mouth. The brand name shown with generic drug entries is for reference only. The reference brand will not have a generic Drug Tier. infrequently, a specific strength or form of the listed drug will not be available as a generic and will be at a different Drug Tier than indicated. For some generic products, the name shown will be the proprietary name of the generic, rather than the generic name. examples: Apri, Microgestin and loxitane. Lamotrigine lamotrigine lamictal disclaimer: every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Lithium, long before lamotrigine lamictal ; , olanzapine zyprexa ; and aripiprazole abilify ; , received the food and drug administration's approval for the maintenance treatment of bd and loxapine. In connection with an equity line arrangement, we issued warrants in December 1999 for 25, 000 shares at a purchase price of $6.875, and in December 2000 for 25, 427 shares at a purchase price of $5.3625, both of which were exercised in the year ended December 31, 2004. We have a commitment to a third party to issue a warrant to purchase 30, 000 shares of our common stock when and if relaxin is approved for a commercial indication. As of December 31, 2004, the warrant had not been issued. Although we sold the relaxin program to BAS Medical in 2003, the warrant obligation was not transferred. We have not reserved any shares for issuance of common stock pursuant to this commitment. 1995 Director Stock Option Plan The Board adopted the 1995 Director Stock Option Plan, or the Directors' Plan, in December 1995, and amended the Plan in 1999, 2001 and 2003. We have reserved a total of 850, 000 shares of common stock for issuance under the Directors' Plan. The Directors' Plan provides for the grant of non-statutory stock options to non-employee directors of Connetics. The Directors' Plan provides that each person who rst becomes a non-employee director is granted a non-statutory stock option to purchase 30, 000 shares of common stock the First Option ; on the date on which he or she rst becomes a non-employee director. Thereafter, on the date of each annual meeting of our stockholders, each non-employee director is granted an additional option to purchase 15, 000 shares of common stock a Subsequent Option ; if he or she has served on the Board for at least six months as of the annual meeting date. Under the Directors' Plan, the First Option is exercisable in installments as to 25% of the total number of shares subject to the First Option on each of the rst, second, third and fourth anniversaries of the date of grant of the First Option; each Subsequent Option becomes exercisable in full on the rst anniversary of the date of grant of that Subsequent Option. The exercise price of all stock options granted under the Directors' Plan is equal to the fair market value of a share of our common stock on the date of grant of the option. Options granted under the Directors' Plan have a term of ten years. Employee Stock Plans We have six plans pursuant to which we have granted stock options to employees, directors, and consultants. In general, all of the plans authorize the grant of stock options vesting at a rate to be set by the Board or the Compensation Committee. Generally, stock options under all of our employee stock plans become exercisable at a rate of 25% per year for a period of four 4 ; years from date of grant. The plans require that the options be exercisable at a rate no less than 20% per year. The exercise price of stock options under the employee stock plans generally meets the following criteria: exercise price of incentive stock options must be at least 100% of the fair market value on the grant date, exercise price of nonstatutory stock options must be at least 85% of the fair market value on the grant date, and exercise price of options granted to 10% or greater ; stockholders must be at least 110% of the fair market value on the grant date. The 2000 Non-Ocer Plan, the 2002 Employee Stock Plan and the International Plan do not permit the grant of incentive stock options. Stock options under all of our employee stock plans have a term of ten years from date of grant. Below is a general description of the plans from which we are still granting stock options. 2000 Stock Plan. Our 2000 Stock Plan the 2000 Plan ; was approved by the Board and our stockholders in 1999. The 2000 Plan became available on January 1, 2000, and was initially funded with 808, 512 shares. On the rst day of each new calendar year during the term of the 2000 Plan, the number of shares available will be increased with no further action needed by the Board or the stockholders ; by a number of shares equal to the lesser of three percent 3% ; of the number of shares of common stock outstanding on the last preceding business day, or an amount determined by the Board. In 2004, the increase in authorized shares was 958, 501. F-20, because lamictal effects.

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Newer aeds such as gabapentin neurontin ; and lamotrigine lamictal ; have advantages, especially for seniors and lamotrigine. The migraine portfolio of Imigran Imitrex and Naramig Amerge grew by five per cent. This reflects a return to growth in the USA, which accounts for three-quarters of sales, where DTC marketing campaigns and migraine awareness programmes were instrumental in increasing sales. In Europe sales were stable, with strong growth in France offsetting declines in other markets. Imigran was launched in Japan in April 2000. Sales of Lamictal, the epilepsy treatment, grew strongly worldwide and particularly in the USA where greater market penetration was achieved in an expanding market. Requip, for the treatment of Parkinson's disease, now marketed in 20 countries, increased sales by 20 per cent, benefiting from the positive outcome of a five-year comparative study published in May 2000. In the smoking cessation market, Zyban's growth of 54 per cent reflects its rollout into European markets following European Union approval in April 2000. Initial sales were particularly strong in the UK and Germany. Respiratory Flixotide Flovent continues to be the world's highest selling asthma medication and is also indicated for chronic obstructive pulmonary disease COPD ; . Sales increased by 29 per cent, notably in the USA where DTC promotion and an expanding market led to a 57 per cent increase in sales. In Europe, where the Group's new combination product, Seretide, has been launched in most markets, sales of Flixotide were maintained despite Seretide's success. Serevent grew by eight per cent. Again growth was particularly strong in the US market, where Seretide has yet to be launched. Seretide, the new combination of Flixotide and Serevent, continues to be successfully rolled out in markets around the world, generating sales of over 200 million in 2000. Significant new markets in 2000 included Spain, Italy and Australia. In the UK and Germany, where Seretide has been available for over a year, it continues to make strong gains in market share. Launch in the USA under the name Advair is planned for April 2001. Approval was received at the end of 2000 to market the product in the European Union in the metered dose inhaler delivery device. Whilst there is an impact on sales of Flixotide and Serevent from the introduction of Seretide, both continue to be leading asthma medications as individual products. Combined sales of Flixotide, Serevent and Seretide increased by almost one-third, indicating their collective strength. In total, anti-asthma COPD sales grew by 16 per cent. This reflects the strong performance of Flixotide, Serevent and Seretide, offset by declining sales of the older asthma products, Ventolin and Becotide, as patients convert to newer products. In the rhinitis sector, growth of Flixonase Flonase is similarly offset by decline in the older product, Beconase. Overall, the Group's products in this sector grew by 12 per cent, supported by DTC advertising in the USA, where over two-thirds of sales are made. But one person in a bipolar support group taking lamictwl had the rash for two weeks before she did anything about it and she's relatively fine, except for having had to stop lajictal cold turkey.

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Dose reduction or cessation of treatment may be required. If liver enzymes become abnormal the dose can be reduced until levels of enzymes become normal and the patient can then continue on this lower dose. Nicotinic acid is. Global pharmaceutical turnover in the fourth quarter of 2004 increased three per cent, reflecting a US turnover increase of four per cent to 2, 114 million; whereas in Europe turnover grew two per cent to 1, 397 million, and in International turnover grew five per cent to 976 million. Turnover in the USA was impacted by generic competition for Wellbutrin and Paxil. Excluding sales of these products, turnover grew 10 per cent in the USA. Pharmaceutical turnover by therapeutic area GlaxoSmithKline's ability to continue to deliver pharmaceutical turnover growth, despite generic competition to several of its products, is primarily due to an exceptionally broad product portfolio of fast-growing, high-value products. These include the respiratory product Seretide Advair, up 19 per cent 2.5 billion ; , the diabetes treatment Avandia Avandamet, up 32 per cent 1.1 billion ; , Lamictzl for epilepsy bipolar disorder, up 32 per cent 0.7 billion ; , Valtrex for herpes 0.6 billion ; , up 24 per cent, Coreg for heart disease, up 34 per cent 0.4 billion ; and vaccines, up 11 per cent 1.2 billion ; . In all, 12 GlaxoSmithKline products each had sales of over 500 million in 2004. Respiratory GlaxoSmithKline continues to be the global leader in respiratory pharmaceuticals with sales of its three key products, Seretide Advair, Flixotide Flovent and Serevent, amounting to 3.4 billion, up nine per cent. Sales of Seretide Advair, the Group's largest product grew 19 per cent to 2.5 billion although this contributed to declines in Serevent and Flixotide, its constituent products. In the USA, Advair sales grew 20 per cent to 1.3 billion. Growth of Seretide in Europe was also strong up 18 per cent to 902 million ; , although reported growth in the fourth quarter was adversely impacted by a one-off rebate adjustment in Germany and wholesaler de-stocking in Italy. International sales grew 15 per cent, reflecting good growth in all geographic areas. The older respiratory products Ventolin and Becotide continued to decline as patients converted to newer products. Central nervous system CNS ; CNS sales declined 16 per cent to 3.5 billion. Sales declined in all regions. Total sales of the Paxil franchise were down 39 per cent to 1.1 billion as a result of generic competition to Paxil IR, sales of which declined 53 per cent to 667 million. Mitigating this decline was the strong performance of the product in Japan, up 25 per cent to 171 million and the performance of Paxil CR which generated sales of 396 million, up 14 per cent. Total sales of Wellbutrin products fell 12 per cent to 751 million. Wellbutrin IR and SR sales fell 64 per cent to 284 million as a result of generic competition. This impact was partially offset, however, by the exceptionally strong performance of Wellbutrin XL, the new once-daily product, which achieved sales of 467 million in its first full year on the market. The strong growth of GlaxoSmithKline's epilepsy and bi-polar disorder treatment Lmictal continues, with sales up 32 per cent to 678 million. Ongoing US growth, up 49 per cent to 414 million, is being driven by the indication for the maintenance treatment of bi-polar disorder received last year. Anti-virals Global HIV product sales rose four per cent to 1.5 billion and sales in the USA increased four per cent to 747 million. GlaxoSmithKline continues to grow its HIV franchise, despite the launch of several new products by competitors. HIV performance was enhanced by the launch of Epzicom, a new combination product Epivir Ziagen ; in the USA in August 2004 and in the EU under the name Kivexa ; in January 2005. Sales of the herpes treatment Valtrex exceeded 500 million for the first time in 2004 up 24 per cent to 571 million ; . Performance is being driven by the USA up 30 per cent to 369 million ; where the product is the clear market leader in treatments for genital herpes. Anti-bacterials Anti-bacterial sales declined nine per cent worldwide and 24 per cent in the USA reflecting generic competition in all regions. Metabolic The diabetes treatments Avandia Avandamet continue to perform very strongly, with overall sales of 1.1 billion up 32 per cent ; . Sales in the USA grew 26 per cent to 852 million. Encouragingly, Avandia Avandamet are also growing very strongly in Europe and International markets with sales up 49 per cent and 62 per cent, respectively. Strong performance in these markets is driven by the growing acceptance amongst opinion leaders and physicians of the benefits of these new products in improving control for diabetic patients. Vaccines The vaccines business had a strong year, with sales up 11 per cent to 1.2 billion. Several key products are driving growth Pediarix Infanrix up 12 per cent to 357 million, Priorix up 14 per cent to 95 million and Fluarix up 38 per cent to 79 million. Oncology and emesis Sales of Zofran grew eight per cent to 763 million, driven by the US performance, up 10 per cent to 565 million. Cardiovascular and urogenital In 2004, Coreg for heart disease ; sales grew 34 per cent to 432 million. Other therapeutic areas Sales of Zantac fell 12 per cent to 273 million with declines in all regions.