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OP.36 The Analysis of Socio-Demographic, Environmental and Individual Factors Associated with Abnormal Eating Attitudes among University Students Ege Ortacgil Department of Psychology, Bilgi University, Istanbul, Turkey The purpose of the present study is to determine the prevalence of abnormal eating attitudes and behaviors among university students. It was hypothesized that the development of abnormal eating attitudes and behaviors would effected by sociodemographical e.g., participants' mothers' educational degree, and employment status ; , environmental e.g., relationships with parents, interference of eating especially from mother in different periods of ages ; and individual e.g., body image distortion ; factors. In addition, attachment styles were expected to predict participants' unhealthy eating attitudes and behaviors. Results reveled that 5% of participants were found to have unhealthy eating attitudes and behaviors and all of them were females. No statistically significant relationship was found between abnormal eating attitudes and behaviors and sociodemographic variables. On the other hand, the findings confirmed the effective role of some of the environmental factors such as receiving negative criticism from family members, partners and peers; and interference of parents concerning eating attitudes and behaviors. Individual factors like BMI and body image discrepancy scores were found to be predictors of unhealthy eating attitudes and behaviors. In addition to all, although preoccupied attachment style was found to be positively correlated with unhealthy eating attitudes and behaviors, when analysis of variance was applied, no statistically significant relation was found between attachment styles and unhealthy eating attitudes and behaviors. OP.37 Cerebellar Morphological Correlates of Neurological Soft Signs in First-Episode Schizophrenia Philipp Thomann1, Martin Roebel1, Vasco Dos Santos1, Silke Bachmann 1 , Christina Bottmer 1 , Ulrich Seidl 1 , Peter Schnknecht1, Marco Essig2, Johannes Schrder1 1University of Heidelberg, Section of Geriatric Psychiatry, Germany 2German Cancer Research Center, Heidelberg, Germany Background: A subtle impairment of motor coordination functions is frequently found in patients with manifest schizophrenia. Clinically these deficits present as neurological soft signs NSS ; . Their morphological cerebral correlates have rarely been investigated. Findings of a previous study of our group using structural magnetic resonance imaging MRI ; showed a significant p 0.05 ; negative correlation between severity of NSS and the volume of the right cerebellar hemisphere. Accordingly, it was hypothesized that substructures of the cerebellum might apply for this association. Methods: To investigate cerebellar substructures and their putative association with NSS, the cerebellum is manually divided on continuous classified, T1 weighted and discrete classified MRI images in the following subsections using BRAINS2 software: anterior lobe, superior posterior lobe, inferior posterior lobe and corpus medullare. Results: In 21 patients with schizophrenia and 10 healthy controls, the cerebellum could be successfully divided in the aforementioned regions. Compared to the healthy controls the subjects with schizophrenia showed a significantly lower volume of the corpus medullare bilaterally. In contrast, the other subregions did not differ significantly between the two groups. In the patient group, statistical analysis revealed a significant p 0.05 ; correlation between NSS score and volume of right, for example, coupons for imitrex.

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6 filed a paragraph IV certification for another patent claiming the same drug. Under this interpretation, multiple companies could be eligible for generic marketing exclusivity, and multiple periods of exclusivity are possible. This is the so-called "patentbased approach." By contrast, Apotex argues that 355 j ; 5 ; B ; should be interpreted to grant generic marketing exclusivity only once i.e., only to the generic manufacturer who filed the first ANDA with a paragraph IV certification for any patent involving a particular drug product, and only based on that first paragraph IV certification. This is the "first-filer approach." Although no court had addressed these competing interpretations before January 2004, the possible tension between them has been apparent since at least 1999. In August of that year, FDA issued a proposed rule that would have adopted the first-filer approach. See 180-Day Generic Drug Exclusivity for Abbreviated New Drug Applications, 64 Fed. Reg. 42, 873, 42, Aug. 6, 1999 ; "August 1999 proposed rule" ; . The agency never implemented the August 1999 proposed rule, however, and instead continued to apply the patent-based approach in disputes surrounding generic marketing exclusivity. See, e.g., Letter from FDA's Office of Generic Drugs "OGD" ; to Genpharm, Inc. of 11 16 01, Joint Appendix "J.A." ; 1124, 1128-30; Letter from OGD to American Pharmaceutical Partners, Inc. of 2 4 03, J.A. 1149, 1152-54. The August 1999 proposed rule was formally withdrawn in 2002. See 180-Day Generic Drug Exclusivity for Abbreviated New Drug Applications, 67 Fed. Reg. 66, 593 Nov. 1, 2002 ; . Before turning to the factual background of the present dispute, we note that the four types of certifications enumerated in 21 U.S.C. 355 j ; 2 ; A ; vii ; are not the only mechanisms by which an ANDA applicant can address a potentially relevant patent. A generic company can instead submit a statement!