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Exaggerated or all-embracing. No special merit was implied. As this was a comparative advertisement mentioning type 2 diabetes and insulin, the group of patients in question should be clear to the health professional. COMMENTS FROM SANOFI-AVENTIS Sanofi-Aventis referred to a recent newsletter from the Medicines and Healthcare products Regulatory Agency MHRA ; No.148 March April 2005 ; , which it considered succinctly summed up its position: `Where secondary endpoint data are being used to promote a product, primary endpoint data and the limitations [emphasis added] of the data must be included too.' `Presenting selected data may exaggerate the benefits of the product and be considered to be in breach of the legislation. We have taken action to correct misleading advertising on the basis of weak comparisons and to ensure that advertising contains information that is sufficiently complete to allow the data to be set in context so that the significance of the findings can be evaluated.' `Care should be taken to present all relevant data to ensure that fair and balanced comparisons can be made, so that any conclusions derived from the advertisement lead to rational prescribing of a product.' Sanofi-Aventis noted that the INITIATE study had been subject to much discussion in the UK and the US. Indeed, in the same edition of the journal, an editorial Davidson 2005 ; compared this to another study Janka et al 2005 ; . This month, two letters to the editor Mikhail et al 2005 and Janka 2005 ; had commented on the comparison of these studies. For each of Clause 7.3 and 7.10, Sanofi-Aventis requested that the Appeal Board considered two points: the limitations of the INITIATE study with respect to methodology target population, concomitant medication and dose schedule ; and its impact on results and the emerging clinical and scientific opinion in the context of other available data. Sanofi-Aventis noted that the target population of the INITIATE study was insulin nave patients with type 2 diabetes. As type 2 diabetes was a progressive chronic illness, this group of patients had very different insulin requirements in those type 2 diabetics who had been on insulin for many years. Sanofi-Aventis alleged that concomitant medication was not addressed in the advertisement at issue and it remained unclear that this subgroup were not taking TZDs. The most important limitations and sources of bias in the study were: the design and implementation of dose titrations and schedules and the population to which the improvement occurred. 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The Latinate "A" ending continues to be very consumer-friendly and popular, as reflected in the top 3 names in this category Aldara, Inspra, and Lunesta. For the sleep aid Lunesta a soothing, calming name that suggests the moon makes a great deal of sense. But for Aldara, and Inspra, which are prescribed for more serious indications genital warts and heart failure respectively ; , the drug companies could have chosen a name that sounds more efficacious or hard-hitting. The popularity of names like Aldara, Inspra, and Lunesta reflects the rise in direct-toconsumer advertising. These names are non-threatening, which makes it easier to talk to consumers about serious conditions. It also makes it easier for consumers to go to their physicians and request a prescription. And if your bottle of Aodara accidentally falls out of your purse, the name sounds so innocuous and friendly that it's not going to cause any embarrassment. Factive, on the other hand, is a very strong name. Factive is an antibiotic, most commonly prescribed for pneumonia or bronchitis, so it's important to telegraph effectiveness with the name. Factive does just that, but is still friendly enough that it doesn't sound like a drug that wreaks havoc on your system. We were surprised to see Abilify score so low, as this goes against the trend that real words or names that are close to real words ; are preferred by consumers. Perhaps the association with "ability" is a little too obvious and people expect their pharmaceutical names to be more coined and scientific-looking.

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Replacement parts must be as originally installed or of equal quality and function. The contractor must agree to redeem manufacturer's warranty on parts where applicable, and further agree to guarantee workmanship and replacement parts, provided by his form for a 90 day period. Bid proposal forms used to submit bids are available from the State Armory Board. Department: Military Affairs Location: PAARNG Armory, Rapps Dam Road, Phoenixville, Chester County, PA Duration: 1 July 96--30 June 99 Contact: Emma Schroff, 717 ; 861-8518 Project No. 157 Provide emergency and routine repair work for plumbing system. The contractor must respond to the call within four 4 ; hours of receiving a call either directly or via a recording device. Replacement parts must be as originally installed or of equal quality and function. The contractor must agree to redeem manufacturer's warranty on parts where applicable, and further agree to guarantee workmanship and replacement parts, provided by his form for a 90 day period. Bid proposal forms used to submit bids are available from the State Armory Board. Department: Military Affairs PAARNG Armory, 143 South Tulpehocken Street, Pine Grove, Location: Schuylkill County, PA Duration: 1 July 96--30 June 99 Contact: Emma Schroff, 717 ; 861-8518 Project No. DGS 985-2 Phase I Project title: Museum Fixed Exhibits. Brief description: installation of permanent fixed exhibits in the Visitors' Center depicting Pontiac's War and Battle of Bushy Run with audio-visual equipment, exhibit graphics and photos and other display systems. General and electrical construction. Plans deposit: $25.00 per set. Payable to: The Commonwealth of Pennsylvania. Refundable upon return of plans and specifications in reusable condition as construction documents within 15 days after the bid opening date. The bidder is responsible for the cost of delivery of the plans and specifications. Contact the office listed below to arrange for delivery of documents. A separate check must be submitted to cover the cost of delivery. Mail request to: The Commonwealth of Pennsylvania, Room 107, Headquarters Building, 18th and Herr Streets, Harrisburg, Pennsylvania 17125. Telephone: 717 ; 787-3923. Bid date: Wednesday, March 27, 1996 at 11: 00 a.m. Pre-bid conference has been scheduled for Thursday, March 7, 1996 at 10: 00 a.m. at the Bushy Run Battlefield. Contact John Giblin, telephone 412 ; 527-5584. All contractors who have secured contract documents are invited and urged to attend this pre-bid conference. 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