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2.3 Stochastic timed automata One of the most important classes of discrete event systems is that of stochastic timed automata. We consider an outcome presentation of these automata corresponding to the notion presented in [10] 6.4. The main differences between an rta and an sta are that in the latter, all random times for the actions are assumed to be independent, and their memory must be encoded into a set of countable states. 9, because diazepam.
Generics lose a considerable part of their price in the first few years of their generic status. This decline could dent the company's margins. Risk mitigation Matrix is aware of this reality and has countered it through an aggressive product development schedule. For instance, the company has launched new products every year since 2000. This increase has served as a shock-absorber. The company is adequately equipped to counter the price decline in select products with a growing volume of stable products. Besides, the company is focused on enhancing productivity, maximising asset utilisation, keeping low overheads and repaying debts by September 2004, an adequate insurance against difficult times.
VISUOSPATIAL PERCEPTION OF LINE ORIENTATION IS RESISTANT TO ONE NIGHT OF SLEEP LOSS Kendall AP, McBride SA, Killgore WD Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA Introduction : Sleep deprivation impairs performance across a spectrum of cognitive abilities including vigilance, attention, and executive function. Although some studies have reported deficits on tasks requiring visual attention and spatial awareness, it is not clear if these impairments are due to altered visuospatial perception or due to reduced attention and vigilance. To clarify this issue, we examined visuospatial and vigilance performance in the same subjects at rested baseline and again following one night of sleep deprivation. Methods : Fifty-four healthy participants 29 male ; participated. Visuospatial performance was assessed at rested baseline and again after, for instance, ibuprofen.
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Note that other approaches, e.g. a sound implementation of the 4-parameter logistic, are also acceptable. See Dudley RA, et al. Guidelines for immunoassay data reduction. Clin Chem 1985; 31: 1264-71 and acetylsalicylic.
A. Difference Between Liability Insurance and Other Primary Insurers.--Liability insurance differs from the other insurance policies or plans that, under 1862 b ; of the Social Security Act, are primary to Medicare. In the case of other types of insurance which are primary to Medicare, i.e., automobile medical and no fault insurance, employer group health plans, and workers' compensation, there is a contractual relationship between the injured party and the third party payer. Thus, the provider has the right to bill the third party payer.
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Because there is insufficient experience available, Because there is insufficient experience available, use is not recommended in children below the age use of this product is not recommended in children of 12 years. below the age of 12 years. If abdominal pain occurs or in cases of any irregularity of faeces, the use of linseed should be discontinued and medical advice must be sought. Linseed should not be used by patients with faecal impaction and symptoms such as abdominal pain, nausea and vomiting unless advised by a doctor because these symptoms can be signs of potential or existing intestinal blockage ileus. ; Linseed should not be used by patients with faecal impaction and symptoms such as abdominal pain, nausea and vomiting unless advised by a doctor because these symptoms can be signs of potential or existing intestinal blockage ileus.
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All older patients with functional impairment or diminished qol as a result of persistent pain are candidates for pharmacotherapy.
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Of the prevalence of comorbidity vary, but up to 50% of people with schizophrenia may have a comorbid drug or alcohol disorder. Comorbid substance disorders are associated with a variety of poorer outcomes in patients with schizophrenia, including increased psychotic symptoms, violence, housing instability and homelessness, medical problems, and poorer treatment compliance. The combination of substance abuse, drug noncompliance, and lack of outpatient contact constitutes a particularly high-risk group. Due to the high degree of comorbidity in this group, patients should be counseled with regard to the hazards of excessive sedation and central nervous system depression associated with the combined use of their drugs with alcohol and other substances of abuse. In addition, other agents prescribed for therapeutic purposes such as benzodiazepines should be prescribed in a prudent fashion due to their inherent abuse potential. Drug Interactions. Drug interactions are another cause of treatment failure that can often be avoided. Both conventional and atypical antipsychotic drugs are extensively metabolized by CYP and other isozymes. Metabolic drug-drug interactions have frequently been observed when antipsychotic agents are coadministered with a variety of other drugs. Of importance, many antipsychotic drugs are converted to active metabolites, which can contribute to the therapeutic or side effects of the parent drug. The clinician needs to be aware of current information concerning the individual CYP isoenzymes involved in the metabolism of antipsychotic drugs. This is essential for the safe, clinical use of this group of drugs Table 1-6, for example, longembolie.
8.1.4.2.4. Combining anticoagulant and platelet-inhibitor therapy. Combinations of oral anticoagulants plus antiplatelet agents to reduce the risk of hemorrhage by allowing lower intensities of anticoagulation or to augment efficacy for selected patients at particularly high risk of thromboembolism, such as those with prior stroke, have been evaluated in several trials. Such a strategy has been successful in reducing the risk of thromboembolism in patients with mechanical heart valves.465 Still another objective of combination therapy is to enhance protection against ischemic cardiac events in patients with AF who have established coronary atherosclerosis or diabetes. In 2 trials, SPAF III and Copenhagen Atrial FIbrillation, Aspirin, and Anticoagulation AFASAK ; 2, the combination of low-dose oral anticoagulation INR less than 1.5 ; with aspirin added little protection against stroke compared with aspirin alone in patients with AF.402, 439 In 2 other trials, substantially higher intensities of anticoagulation combined with platelet inhibitor agents were evaluated in patients with AF. The French FluindioneAspirin Combination in High Risk Patients With AF FFAACS ; study compared the oral anticoagulant fluindione target INR 2.0 to 2.6 ; plus placebo or in combination with aspirin, 100 mg daily, versus fluindione alone in patients at high risk of stroke. The trial was stopped with only 157 patients enrolled mean follow-up 0.84 y ; because of excessive hemorrhage in the group receiving the combination therapy.433 In the larger Spanish National Study for Primary Prevention of Embolism in Nonrheumatic Atrial Fibrillation NASPEAF ; study, patients were stratified into a high-risk group n 495 ; with AF and rheumatic mitral stenosis or AF and a history of stroke, TIA, or systemic embolism, and a lower-risk group n 714 ; with AF and age greater than 60 y, hypertension, or HF.445 The higher-risk patients were randomized to anticoagulation with acenocoumrarol target INR 2.0 to 3.0 ; or to acenocoumarol INR 1.4 to 2.4 ; combined with the platelet cyclooxygenase inhibitor triflusal 600 mg daily ; . The lower-risk patients were randomized to triflusal alone, acenocoumarol alone INR 2.0 to 3.0 ; , or the combination of triflusal plus acenocoumarol INR 1.25 to 2.0 ; . The achieved anticoagulation intensities in the anticoagulation and combination therapy arms were closer to one another than intended, however mean INR 2.5 with acenocoumarol alone in both risk strata versus 1.96 and 2.18 for the combination arms in the lower- and higher-risk groups during median follow-up of 2.6 and 2.9 y, respectively ; . The primary outcome was a composite of thromboembolism plus cardiovascular death sudden death or death due to thromboembolism, stroke, bleeding, or HF but not MI ; . Patients in both risk categories had a lower risk of primary events with the combination therapy than with acenocoumarol alone. These observations suggest that a combination of platelet inhibitor and anticoagulant therapy might be effective and relatively protective if targeted INR levels are closer to the standard range, but the superiority of combination therapy over monotherapy with a vitamin K antagonist for prevention of ischemic stroke and MI has not been convincingly established. Combining aspirin with an oral anticoagulant at higher intensities may accentuate intracranial hemorrhage, particularly in elderly AF patients.466 In a retrospective analysis of 10 093 patients with AF after hospital discharge mean age 77 y ; , platelet inhibitor medication was associated and amantadine.
Alcohol addiction and dependence aren't always diagnosed in the same way as other drugs which cause chemical dependence. A recent study revealed that sixty five per cent of GPs help just one to six patients with serious drink problems at any given time, yet there are likely to be 360 excessive drinkers on an average GPs list of 1, 800 people. More specifically, the rise in women's drinking is a healthcare timebomb which is about to explode, according to Dr. Neil Brener, Medical Director, The Priory Hospital North London, for example, diclofenac.
Since its inception in 1999, Avera Health Plans AHP ; has attempted to make claims submission a painless process for all providers. Even though AHP will accept claims submitted via Electronic Data Interchange EDI ; or by mail RRI ; , it is proven that electronically submitted clean claims are paid in the most timely and efficient manner. After reviewing data reports, AHP has found that claims pay approximately 30% faster when submitted electronically. There are many EDI options available to help convert your practice management software into a readable file for electronic transmission. AHP's clearinghouse of choice is WebMD payor number 46045 ; . Please consider submitting your claims electronically to save you time and money. AHP will assist, at your request, in answering questions about electronic claims transmission. Please contact AHP at 888 ; 322-2115 or 605 ; 322-4545 for additional questions and amiloride.
The legitimate use of controlled drugs is regulated by the misuse of drugs regulations, which divides controlled drugs into five schedules 1, 2, 3, and 5 ; of varying degrees of control!
Y quarters included eight cots and a communal bathroom with one toilet that had to be filled with water before flushing. And, still, there was no guarantee that it would flush. A large tin basin, for bathing, lay on the floor. Having been advised not to drink the water, I nonetheless curiously turned the knob of the faucet, which produced only air. Water would be brought to us from the well, for bathing. I was in the poorest country in the Western hemisphere. I wondered if my 35 bottles of water were going to be enough for drinking as well as bathing. I met the Haitian attending with whom I would be working. I tried to explain my position as a second-year resident. He clarified my position as a doctor, and explained that there would be many patients and my clinical judgment would be my own. In fact, he wanted to learn American practices of medicine from me. Clinic was to start promptly at seven the following morning. I did not get much sleep that night. The heat, musk and mold and
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Registered nurses from the Minnesota Department of Health MDH ; use this Licensing Survey Form during on-site visits to evaluate the care provided by Class A Licensed-Only Home Care Providers. Class A licensees may also use this form to monitor the quality of services provided to clients at any time. Licensees may use their completed Licensing Survey Form to help communicate with MDH nurses during an on-site regulatory visit. During an on-site visit, MDH nurses will interview staff, clients and or their representatives, make observations and review documentation. The survey is an opportunity for the licensee to describe to the MDH nurse what systems are in place to provide Class A Licensed-Only Home Care services. Completing this Licensing Survey Form in advance may facilitate the survey process. Licensing requirements listed below are reviewed during a survey. A determination is made whether the requirements are met or not met for each Indicator of Compliance. This form must be used in conjunction with a copy of the Class A Licensed-Only Home Care regulations. Any violations of the Class A licensing requirements are noted at the end of the survey form. Name of Class A Licensee: HEALTHCARE RESOURCES HFID #: 24274 Date s ; of Survey: January 30, 31, and February 1, 2, 5, and 6, 2007 Project #: QL24274002 Indicators of Compliance.
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RECENT ADVANCES IN ISOLATION techniques for cholangiocytes and bile duct units have resulted in the rapid expansion of knowledge about bile duct epithelial cell biology and physiology 3, 6, 15, ; . However, most isolated cholangiocyte preparations have certain inherent limitations due to low cell yield and diminishing viability after isolation as well as the excessive labor and cost involved in the isolation procedures. Isolated cell preparations and established cholangiocyte cell lines also lose cell polarity and local cellular contacts, which are vital for various aspects of epithelial cell physiology such as ion transport and expression of cellular proteins. Cholangiocyte cell lines established from rats or humans also raise concerns about clonal and
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Read the full abstract for more clinical points. I believe our number one goal of primary care should be making all persons take responsibility for their own health and well-being by adopting healthy habits. Some primary care clinicians have a weight problem. This may deter them from confronting obese patients about their problem. Some clinicians may be discouraged about advising obese patients because of a perceived lack of effectiveness of treatment. I can think of no more simple, no-cost, and potentially valuable measure to reduce risk of disease than weight loss. If only it were not so difficult.
There is an old clich that says, "I don't have to tell everyone how great that person was." Well, that doesn't pertain to this message, because I do want to tell everyone how great Mike Motta was. Mike was a great man and he was a great Brother for our Union. I first met Mike when he was teaching FacRep training for the Northwest Mountain Region. The dedication and expertise he had in this area was very impressive. He crafted brilliant informational binders for each FacRep and Activist for these classes that were second to none. He went through these books in an organized fashion while teaching the course, and there is no doubt that I learned a great amount about labor relations and the NATCA Contract from Mike. In large part, Mike generously helped to aide in my education of NATCA. I also met up with Mike at various NATCA functions. The smile on his face was constant and the laughter from him was always uplifting. Mike was truly a joy to always be around, and when we did little things like go to eat dinner, I made it a point to sit at the same table as him. Mike worked very hard for Mike, Michelle, and Irene at the hospital NATCA. His knowledge of the Contract, MOU's, LMR and everything else involved was incredible. He helped make the Northwest Mountain Region membership become unified both as the Alternate RVP for James Ferguson and as the FacRep of Seattle TRACON. He loved our Union and he loved helping the membership. The time away from his family and personal life to help NATCA makes him one of the true heroes of our Union. Mike, thank you for being you, and for everything you did. You will be sorely missed and never forgotten. Doug Laughter NATCA National Communications Committee and
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Appropriate history, physical examination, and medical decision-making based on the initial evaluation of a patient's presenting symptoms are essential. The guidelines of the Centers for Medicare and Medicaid Services CMS ; provide various criteria for five levels of services 258 ; . The three crucial components of evaluation and management services are: history, physical examination, and medical decision-making. Other components include counseling, coordination of care, nature of presenting problem and time required for face-to-face evaluation. While there are numerous techniques to evaluate a chronic pain patient, which vary from physician to physician, institution to institution and textbook to textbook, following the guidelines established by CMS will assist a physician in performing a comprehensive and complete evaluation complying with regulations.
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Initiation of protease inhibitor treatment. All subjects had normal routine laboratory screening results including normal liver function tests and urinalysis. None of the subjects had a family history of diabetes. Normal glucose tolerance had been ascertained by fasting plasma glucose levels 6 mmol l and plasma glucose levels 7.8 mmol l 2 h after a 75-g oral glucose load 17 ; . The drug that patients received was based on the clinical judgment of their physician. Table 1 gives the drug regimens of individual patients before and after protease inhibitor treatment. Eight subjects NRTI pretreated ; had been on a combination therapy of nucleoside analogues and a non-NRTI for at least 12 months; the NRTIs were continued throughout the study, the non-NRTI was discontinued, and a protease inhibitor was added. Five subjects NRTI naive ; , who were drug naive, were started on two NRTIs plus a protease inhibitor. Thus, during the treatment phase all patients were on a combination of a protease inhibitor and NRTIs. None of the subjects experienced any subcutaneous fat wasting before or throughout the study. All were studied on three occasions: once before initiation of protease inhibitor treatment and at 6 and 12 weeks thereafter. Only results of those before and at 12 weeks are reported. Subjects consumed a weight maintenance diet containing 200 300 g carbohydrate at least 3 days before the first hyperglycemic clamp experiment and throughout the whole 12-week study period. On each study occasion subjects were admitted to the clinical research center at 5: 00 P.M. the day before the experiment. Between 6: 00 P.M. and 7: 00 P.M. a standard dinner 10 kcal kg: 50% carbohydrate, 35% fat, and 15% protein ; was given. At 5: 00 A.M. the following morning, primed-continuous infusions of [6, 6-2H2]glucose 24 mol kg, 0.24 mol kg 1 min 1 ; and [9, 10-3H]palmitate 0.8 Ci min ; were started via a forearm vein. At 6: 00 A.M. a retrograde venous catheter was inserted into a dorsal hand vein and maintained in a thermoregulated box at 65C to obtain arterialized blood samplings 18 ; . After allowing at least 2 h to achieve isotopic steady state, baseline samples for substrate enrichments, specific activities, plasma glucose, FFAs, glycerol, insulin, glucagon, C-peptide, and proinsulin concentrations were collected at 30, 15, and 0 min. Just before beginning the clamp, subjects took their medications. Subsequently, a primed 150 mg kg body wt ; 20% glucose infusion was given and plasma glucose levels were clamped at 10 mmol l 180 mg dl ; for 3 h 19 ; Plasma insulin, proinsulin, and C-peptide concentrations were measured at 2.5, 5.0, 7.5, and 180 min. Samples for plasma glucose, FFA, glucagon, glycerol concentrations, enrichments, and specific activities SAs ; were collected during the last hour of the clamp at 20-min intervals 120, 140, 160, and 180 min ; . Plasma glucose was measured at 5-min intervals throughout for adjustments of glucose infusion rates using a glucose analyzer YSI Glucose Analyzer; Yellow Springs Instruments ; . Plasma insulin Linco Research ; , proinsulin Linco Research ; , C-peptide Diagnostic Product ; , and glucagon Linco Research ; were measured by standard radioimmunoassays. Plasma FFA levels were measured by an enzymatic calorimetric method NEFAC; Wako Pure Chemical ; . Plasma glycerol concentrations were determined by standard microfluorometric assays 20 ; . HbA1c was determined by high-performance liquid chromatography HPLC ; . Plasma [6, 6-2H2]glucose enrichments were measured by gas chromatoDIABETES, VOL. 52, APRIL 2003.
The numerous pharmacologic and device therapies available for heart failure present the healthcare provider with a dizzying set of choices. Standard therapy would employ beta-blockers as well as agents that affect the renin-angiotensin system. The evidence derived from a multitude of trials conducted with ACE inhibitor ARBs and beta-blocker therapy have documented the effectiveness of these agents in: a ; improving the clinical stage of the patient, b ; reducing the symptoms reported by the patient, and c ; decreasing the mortality risk of the patient with heart failure. The astute clinician is aware of several qualifications in the utilization of ACE inhibitors and beta-blockers. Some of which I have incorporated into my practice include the fact that: a ; ACE inhibitor ARB and beta-blockers may be started contemporaneously, b ; the ACE inhibitor ARB that is chosen or beta-blocker employed should be titrated to the dose which was evaluated in the trials and which the data suggested provided the benefit achieved, and c ; these agents must be used cautiously in individuals who exhibit low systemic blood pressures 85 mm, because ibuprofen.
Professor Owen Wade was Whitla Professor of Therapeutics and Pharmacology at Queen's University, Belfast from 1957 to 1971, then Professor of Therapeutics and Clinical Pharmacology at Birmingham from 1971 to 1986. He was Deputy Chairman of the Adverse Reactions Committee, Committee on Safety of Drugs from 1963 to 1968 and Chairman of Committee on the Review of Medicines from 1978 to 1984. See his autobiography, When I Dropped the Knife. Bishop Auckland: Pentland Press, 1996 and
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Minnesota medicine published monthly by the minnesota medical association november 2003 volume 86 pulse news digest weighing in extreme obesity in americans has sharply risen the number of americans who are extremely obese quadrupled between 1986 and 2000, according to a report published in the october issue of archives of internal medicine.
The menopause or climacteric is the time in a woman's life when the menstrual periods stop coming. After menopause, she can no longer bear children. In general, this `change of life' happens between the ages of 40 and 50. The periods often become irregular for several months before they stop completely. There is no reason to stop having sex during or after the menopause. But a woman can still become pregnant during this time. If she does not want to have more children, she should continue to use birth control for 12 months after her periods stop. When menopause begins, a woman may think she is pregnant. And when she bleeds again after 3 or 4 months, she may think she is having a miscarriage. If a woman of 40 or starts bleeding again after some months without, explain to her that it may be menopause. During menopause, it is normal to feel many discomforts--anxiety, distress, `hot flashes' suddenly feeling uncomfortably hot ; , pains that travel all over the body, sadness, etc. After menopause is over, most women feel better again. Women who have severe bleeding or a lot of pain in the belly during menopause, or who begin to bleed again after the bleeding has stopped for months or years, should seek medical help. An examination is needed to make sure they do not have cancer or another serious problem see p. 280 ; . After menopause, a woman's bones may become weaker and break more easily. To prevent this, it helps to eat foods with calcium see p. 116 ; . Because she will not have any more children, a woman may be more free now to spend time with her grandchildren or to become more active in the community. Some become midwives or health workers at this time in their lives.
Approved in the United States as therapy for chronic HBV infection in 1992, interferon alfa-2b is thought to work by affecting viral replication and, as an immunomodulator, by up-regulating cytokines involved in the response to infection. Predictors of successful therapy include low HBV DNA levels, elevated transaminase levels, lack of fibrosis on liver biopsy, female sex, and absence of HIV coinfection.16 Contraindications to interferon alfa-2b therapy include preexisting neutropenia, thrombocytopenia, severe uncontrolled depression, decompensated cirrhosis, and current alcohol or drug abuse. Because interferon alfa-2b has numerous side effects, tolerance is a problem in many patients. Overall, 46 percent of patients treated with interferon alfa-2b have HBeAg seroconversion in the first year after treatment.8 Hepatitis B surface antibody anti-HBs ; develops in 8 percent of treated patients. Follow-up studies five to 10 years ; in North America and Europe have demonstrated 80 to 95 percent persistence of HBeAg negativity.6 Response rates and durability of response are significantly lower in neonates and Asians. To date, long-term follow-up has demonstrated two different patterns of benefit from interferon alfa-2b therapy in patients with chronic hepatitis B: 1 ; reduction in mortality from hepatocellular carcinoma in Asian patients, and 2 ; decreased mortality from decompensated cirrhosis in North American and European patients.6.
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Listen with regard when client speaks. Encourage individuals not to answer to everything. Communicate message of separation--that it is acceptable for family members to be different from each other. Encourage and allow expression of feelings e.g., crying, anger ; by individuals. Prevent intrusion in dyads by other members of the family. Reinforce importance of parents as a couple who have rights of their own, for example, acenoclumarol sintrom.
All interaction studies conducted in healthy volunteers. Patients received tenofovir DF 300 mg once daily. Increase ; Decrease ; No Effect REYATAZ Prescribing Information Bristol-Myers Squibb Company ; In HIV-infected patients, addition of tenofovir DF to atazanavir 300 mg plus ritonavir 100 mg, resulted in AUC and Cmin values of atazanavir that were 2.3- and 4-fold higher than the respective values observed for atazanavir 400 mg when given alone.
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ASYSTOLE PULSELESS ELECTRICAL ACTIVITY PEA ; - PEDIATRIC REGIONAL ALS PROTOCOL Criteria: A. Pediatric cardiac arrest patient presenting with asystole or potentially perfusing electrical rhythm but has no discernable pulses. Procedure: A. See accompanying flowchart. Possible MC Orders: A. Atropine 0.02 mg kg IV IO or ETT. Minimum dose 0.1 mg, Maximum dose 0.5 mg. May be ordered to be repeated once after 3-5 minutes. B. Glucagon if available ; 0.5 mg kg IV if suspected blocker overdose or calcium channel blocker overdose that is unresponsive to calcium chloride. C. Calcium chloride if available ; 0.2 ml kg of 10% solution if suspected calcium channel blocker overdose or hyperkalemia. Notes: 1. Confirm the presence of asystole in two lead positions. 2. Confirm and document ETT placement with ETCO2 detector. Consider false negatives with asystole and prolonged arrest time. Listen for and document equal bilateral breath sounds in the chest and an absence of sounds over the epigastrium. 3. If unable to obtain intravenous IV ; access, place an intraosseous IO ; line. Once established, the IO line replaces the IV line as the primary route of administration for fluid and medications. 4. When given IV IO, Epinephrine should be repeated every 3-5 minutes. Only the first IV IO dose is given as 1: 10, 000 0.01 mg kg ; . All subsequent IV IO doses are given as 1: 000 0.1 mg kg ; . If IV unsuccessful, Epinephrine 0.1 mg kg may be administered via endotracheal tube. All ET doses are 0.1 mg kg 1: 000 ; . 5. Medical Command physician may order Atropine 0.02 mg kg IV IO or ETT. Minimum dose 0.1 mg, Maximum dose 0.5 mg. May be ordered to be repeated once after 3-5 minutes. 6. On pediatric patients, it is strongly recommended to utilize a Broslow Tape or other similar commercially available reference.
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