Before the lambskin incident, for example, she marched around, chatting giddily about camp: "Today, today, today, we, um, instead of two periods of the game thingies, they call it sessions, periods, each session or whatever, we went to the picnic tables and we all went to the picnic tables and it was really fun." Haley's parents struggled to track her unspooling sentences and scrambled thoughts. "Did you follow the bouncing ball?" Ms. Abaspour asked her husband, who replied, "I don't even see the ball, honey." Haley sighs, frowns and fidgets, eyes drooping before she falls apart. Sometimes she hyperventilates or crawls under a table. It always ends with crying, but sometimes she will start to laugh through her tears, becoming "all chipper again, like manic, " Mr. Abaspour said. Adds Ms. Abaspour: Later, "she says, `I'm sorry, I'm sorry, ' apologizing for who she is." Her father said: "It's not like a hurt that you can kiss better. It comes from within, and she doesn't know why, and you can't do anything about it." A Mother's Stoicism Christine Abaspour, the youngest of four girls raised by a divorced mother, knew what she wanted early in life. At 19, she left Massachusetts, joined a sister in Florida and became a waitress. At 25, she met her husband-to-be, who was 11 years older. She was engaged in two weeks, married in nine months and a mother a year later. "We both wanted to have children right away, like you wouldn't believe, " she recalled. Ms. Abaspour said that she had no regrets, and that Haley "was given to us for some reason, and I keep waiting for the day when I realize why." Still, the experience has tested her stamina, and she avoids capitulating to Haley's whims and outbursts by imposing structure, consistency, even distance. "I'm her mother, " Ms. Abaspour said. "I try to make it a better world for her, a more comfortable world. I stay very strong for her and very encouraging for her. If she comes out of a meltdown, I'll say, `I knew that you could.' I don't make her feel totally.
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1362 ENDOCRINE INFLUENCE ON THE MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF THE LACRIMAL GLAND SULLIVAN DA, SUZUKI T, SCHIRRA F, RICHARDS SM, SULLIVAN BD, SULLIVAN RM, SCHAUMBERG DA, DANA MR, LIU M Schepens Eye Research Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Purpose: Significant, sex-related differences exist in the structure and function of the lacrimal gland and may contribute to the female-related prevalence of dry eye syndromes. We hypothesize that this sexual dimorphism is due, at least in part, to sex steroid influence. Our research was designed to test this hypothesis. Methods: Methods included animal experiments, cell cultures, biochemical, histological and molecular biological procedures, and clinical and epidemiological studies. Results: Our results, as well as those of others, demonstrate that androgens, estrogens and progestins modulate the anatomy, biochemistry, physiology, immunology, gene expression and or secretion of the lacrimal gland. These hormone actions appear to account for many of the sex-associated differences in this tissue. Of particular interest, androgens reduce the inflammation in, and enhance the functional activity of, lacrimal glands in mouse models of Sjgren's syndrome. In contrast, estrogens may interfere with lacrimal gland function and promote aqueous-deficient dry eye. Conclusions: Our findings show that sex steroids exert a significant impact on the lacrimal gland in both health and disease. Supported by research grants from NIH [EY05612, EY12523, EY00365, CA47988 & HL43851], Allergan, German Research Society DFG and the Joint Clinical Research Center of Schepens Eye Research Institute and the Massachusetts Eye & Ear Infirmary ; 1364 THE MEIBOMIAN CONTRIBUTION TO OCULAR SURFACE HEALTH AND DISEASE - THE ROLE OF MEIBOMIAN LIPID BRON AJ Oxford The meibomian glands are richly innervated, tubulo-acinar, holocrine glands, supplied with both androgen and oestrogen receptors. They secrete lipid continuously to a lid margin reservoir. The preocular lipid film is reconstructed in the up-phase of each blink and is compressed into the reservoir with lid closure. The lipid layer retards evaporation, resists contamination by skin lipid and traps inert and infective particles . Deficiency of tear film lipid arises from congenital absence or replacement of the glands and may be part of an inherited disorder such as dystichiasis-lymphoedema syndrome or ectodermal dysplasia. The commonest cause of oil deficiency is meibomian gland dysfunction MGD ; , which may be primary or secondary. Obstructive MGD may be secondary to a range of skin disorders, including acne rosacea and atopic and seborrhoeic dermatitis. Cicatricial MGD may be seen in a primary form as a limited exposure of the terminal ductules of the meibomian glands. Otherwise it is found as a feature of the cictricial conjunctivitides such as erythema multiforme, ocular pemphigoid and atopic keratocunjunctivitis or preservative toxicity. Congenital meibomian gland deficiency may cause only mild signs of ocular surface damage while in MGD surface damage and ocular symptoms may be major and give rise to the clinical syndromes of meibomian keratoconjunctivitis and evaporative dry eye. The role of micro-organisms and of inflammatory mediators in these clinical disorders will be discussed and
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CONCLUSION 1. ; The results show that high performance liquid chromatography with diode array detector HPLC DAD ; is a robust and simple analytical method for determination of the veterinary antibiotics in water samples. The method was fully fit for purpose for these fate studies with suitable recoveries TABLES ; , limit of detection LOD ; and limit of quantification LOQ ; . LOD and LOQ for determination at 254 nm were calculated: ENRO [2 g mL, 3 g mL]; OTC [1 g mL, 2g mL], and TMP [0.5 g L, 1 g mL], respectively. 2. ; Optimization of HPLC separation was accomplished using genetic algorithm approach. The best separation was achieved using 0.5% formic acid and 1% trifluoroacetic acid in 0.05 M ammonium acetate pH 2 ; methanol, 70 + 30 v the optimum mobile phase. 3. ; Recovery experiments TABLES ; show that the best efficiency of the extraction procedure was accomplished on SDB disks with 2x10 mL methanol or ethanol pH 3 ; , but ethanol is recommended because of its less toxicity. ACKNOWLEDGMENTS This work was financially supported by the European Union, and reflects only the autor's views and the European Community is not liable for any use that maybe made of the information contained in INCO-WESTERN BALKAN FP6 ; project "Reduction of environmental risks posed by Emerging Contaminants, through advanced treatment of municipal and industrial wastes EMCO ; [INCO-CT-2004-509188].
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Class: nucleoside analog also called nucleoside reverse transcriptase inhibitor, NRTI, or nuke ; Standard dose: One 0.75 mg tablet three times a day, take on an empty stomach. Liquid available through compassionate use program. Take missed dose as soon as possible, but do not double up on your next dose. AWP: $273 month Manufacturer contact: Roche Pharmaceuticals, rocheusa , 1 800 ; 2827780 AIDS Treatment Information Service: 1 800 ; HIV0440 4480440 ; Potential side effects and toxicity: Peripheral neuropathy tingling, burning, numbness or pain in the hands or feet ; may go away once Hivid is stopped, but can be painful and permanently debilitating if not treated in time. Other side effects include headache, fever, skin eruptions, sores or swelling in the mouth, nausea, and pancreatitis. Rare but potentially fatal toxicity with all NRTIs is pancreatitis inflammation of the pancreas ; , hepatomegaly enlarged liver ; with steatosis and lactic acidosis accumulation of lactate in the blood and abnormal acid-base balance ; . Lactic acidosis has been seen in patients taking NRTIs but is more common and more severe in women, people who are obese and people who have been taking nukes for a long time; and more common in people with liver disease, but can occur in people without a history of liver damage. People with lactic acidosis may experience persistent fatigue, abdominal pain or distension, nausea vomiting, and difficulty breathing or shortness of breath; and enlarged, fatty liver called hepatomegaly with steatosis ; . People with a history of peripheral neuropathy, pancreatitis or heavy alcohol use should avoid Hivid. Pancreatitis can be life-threatening and may cause pain in the stomach and back, along with nausea, vomiting and blood in the urine. Your physician will check for pancreatitis by checking for increased levels of amylase and lipase in the blood. Risks for pancreatitis include: higher than recommended doses of NRTIs, advanced HIV, and alcohol use. Body fat redistribution accumulation has also been reported with Hivid. With few exceptions, these side effects are stronger than is seen with other NRTIs. Potential drug interactions: Due to increased risks associated with peripheral neuropathy, Hivid should not be taken with Videx ddI ; or Zerit d4T ; . Epivir 3TC ; should also be avoided as it can lower the levels of Hivid in the body. Other medications that can interact with Hivid include Antabuse disulfiram ; , Fungizone amphotericin B ; , Benemid probenecid ; , Chloromycetin chloramphenicol ; , certain chemotherapy agents, Dilantin phenytoin ; , dapsone, Foscavir foscarnet ; , isoniazid, Flagyl metronidazole ; , hydralazine, ribavirin, and Macrodantin Macrobid nitrofurantoin ; . When used at the same time as Tagamet cimetidine ; and Benemid probenecid ; monitor for renal toxicity. Maalox and Foscavir may decrease Hivid levels. When used with Hivid, pentamidine NebuPent, Pentam or Pentacarinat, used for treating Pneumocystis jiroveci pneumonia PCP ; , may increase risk of pancreatitis. Hivid should not be taken at the same time with antacids containing magnesium or aluminum, as they may decrease levels of Hivid in the body. Tips: For a long time rarely used, Hivid is being prescribed more in salvage therapy. Hivid should be avoided if you are pregnant or breast feeding. Notify your doctor immediately if peripheral neuropathy is suspected, but do not stop medication unless directed to do so your healthcare provider.
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