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Prescription volumes for gastrointestinal drugs for each period are summarized in Table 1. The 12-month period from September 1994 to August 1995 was considered the baseline against which we evaluated the impact of the reference-based pricing and special authority policies, because it immediately preceded the announcement and implementation of these policies. During the baseline period, the mean monthly number of defined daily doses of H2RAs prescribed was 137 855 per.

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